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Engineered and multimerized human immunodeficiency virus envelope glycoproteins and uses thereof

  • US 10,342,863 B2
  • Filed: 03/24/2016
  • Issued: 07/09/2019
  • Est. Priority Date: 03/24/2015
  • Status: Active Grant
First Claim
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1. An engineered and multimerized (e/m) human immunodeficiency virus (HIV) envelope glycoprotein (Env) comprising:

  • (i) mutations, using HXB2 numbering;

    N460D;

    N463D;

    S278R;

    G471S;

    V65C; and

    S115C;

    (ii) removal of the V1 loop and the V2 loop;

    (iii) replacement of the V3 loop with a flexible linker;

    (iv) an N-terminal truncation; and

    (v) a heptamerization domain;

    wherein the e/m Env does not include a mutation at position 276.

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