Methods and systems for delivering substances into luminal walls
First Claim
Patent Images
1. A method for delivering an active substance to a luminal site, the method comprising:
- providing a device comprising;
a catheter body having a proximal end and a distal end;
an expandable shell;
a scoring structure having a proximal end and a distal end, comprising at least one scoring element disposed near the distal end of the catheter body and over the expandable shell, wherein one of the proximal end and the distal end of the scoring structure is fixed to the catheter body and the other of the proximal end and the distal end of the scoring structure is axially slidable with respect to the expandable shell;
an active substance carried by the at least one scoring element;
positioning the at least one scoring element within a body lumen; and
expanding the expandable shell to cause movement of the at least one scoring element, the at least one scoring element thereby penetrating an occlusion at the luminal site within the body lumen, the active substance being released from the at least one scoring element into the occlusion at the luminal site as a result of the penetration.
3 Assignments
0 Petitions
Accused Products
Abstract
Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The scoring elements have drugs and other active substances coated over a portion thereof or incorporated within internal structure of the element so that the drug is released into the luminal wall closely associated diseased regions of the body lumen as the scoring structure is radially expanded into the wall.
-
Citations
19 Claims
-
1. A method for delivering an active substance to a luminal site, the method comprising:
-
providing a device comprising; a catheter body having a proximal end and a distal end; an expandable shell; a scoring structure having a proximal end and a distal end, comprising at least one scoring element disposed near the distal end of the catheter body and over the expandable shell, wherein one of the proximal end and the distal end of the scoring structure is fixed to the catheter body and the other of the proximal end and the distal end of the scoring structure is axially slidable with respect to the expandable shell; an active substance carried by the at least one scoring element; positioning the at least one scoring element within a body lumen; and expanding the expandable shell to cause movement of the at least one scoring element, the at least one scoring element thereby penetrating an occlusion at the luminal site within the body lumen, the active substance being released from the at least one scoring element into the occlusion at the luminal site as a result of the penetration. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
Specification