Vagus nerve stimulation responsive to a tachycardia precursor

• US 10,342,978 B2
• Filed: 03/30/2016
• Issued: 07/09/2019
• Est. Priority Date: 12/24/2003
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Libbus, Imad
• Primary Examiner(s): Mahmood, Nadia A
• Application Number:
  US15/085,799
• Publication Number:
  US 20160206881A1
• Time in Patent Office: 1,196 Days
• CPC Class Codes: A61N 1/36117 for treating hypertension
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

A vagus nerve neurostimulator may comprise a pulse generator, a lead and a controller. The pulse generator may be configured to generate a pulsed electrical signal comprising an ON time, an OFF time, an amplitude, a frequency, a pulse width, and a duty cycle. The lead may be electrically connected to the pulse generator. The pulse generator may be configured to cooperate with the lead to apply an electrical signal from the pulse generator to the vagus nerve to provide therapeutic effects for a neurostimulation therapy at an intensity that avoids physiological side effects. The controller may be configured to use stored parameters in a memory to deliver neurostimulation to the vagus nerve before detection of a precursor to a tachycardia, detect the precursor, and respond to the detected precursor by temporarily changing an intensity of the delivered neurostimulation.

Claims

1. A method performed using a vagus nerve stimulator that includes a pulse generator configured to generate a pulsed electrical circuit comprising an ON time, an OH time, an amplitude, a frequency, a pulse width and a duty cycle, includes a lead with an electrode electrically connected to the pulse generator, and includes a controller, the method comprising:

storing stimulation parameters in a memory of the vagus nerve neurostimulator;

controlling the pulse generator, using the controller and stored stimulation parameters, to deliver neurostimulation to a vagus nerve before detection of a precursor to a tachycardia, wherein deliver neurostimulation includes deliver the electrical therapeutic stimulation to the vagus nerve to provide therapeutic effects for a cardiac therapy at an intensity that avoids physiological side effects, wherein the deliver the electrical therapeutic stimulation includes deliver neurostimulation pulses in bursts, wherein the bursts are delivered during the ON time and are not delivered during the OFF time, and wherein the pulses have a pulse frequency and the bursts have a burst frequency; and

use the controller to detect the precursor and respond to the detected precursor by temporarily changing an intensity of the delivered neurostimulation for the cardiac therapy.

2. The method of claim 1, wherein controlling the pulse generator includes controlling the intensity of the delivered neurostimulation using a circadian rhythm.

3. The method of claim 2, wherein the memory includes a circadian rhythm template stored therein, and wherein controlling the intensity of the delivered neurostimulation includes using the circadian rhythm template stored in the memory to control the intensity of the delivered neurostimulation.

4. The method of claim 1, further comprising sensing patient activity, wherein controlling the pulse generator includes controlling the intensity of the delivered neurostimulation using sensed patient activity.

5. The method of claim 4, wherein sensing activity includes using an accelerometer to sense activity.

6. The method of claim 4, wherein sensing activity includes using sensing minute ventilation.

7. The method of claim 1, further comprising identifying an adverse event and delivering the electrical therapeutic stimulation for the identified adverse event.

8. The method of claim 1, further comprising, upon detecting an absence of a condition indicative of tachyarrhythmia, switching to delivering normal electrical therapeutic stimulation to the vagus nerve.

9. The method of claim 1, wherein controlling the pulse generator to respond to the detected precursor by temporally changing an intensity of the delivered neurostimulation includes controlling the pulse generator to compare an acquired parameter to a target parameter to tune the intensity of the delivered neurostimulation.

10. The method of claim 1, wherein the stimulation parameters include an amplitude, a duty cycle, a frequency and a pulse width, and wherein controlling the pulse generator to respond to the detected precursor by temporarily changing the intensity of the delivered neurostimulation includes increasing the amplitude, increasing the duty cycle, increasing the frequency or increasing the pulse width.

11. The method of claim 1, wherein controlling the pulse generator includes controlling the pulse generator, using the controller and the stored parameters, to detect a bradyarrythmia and suspend the electrical therapeutic stimulation in response to detecting the bradyarrythmia.

12. A vagus nerve neurostimulator, comprising:

a pulse generator configured for use to deliver neurostimulation to a vagus nerve, wherein the pulse generator is configured to generate a pulsed electrical signal comprising an ON time, an OFF time, an amplitude, a frequency, a pulse width, and a duty cycle;

a lead with an electrode electrically connected to the pulse generator, wherein the pulse generator is configured to cooperate with the lead to apply an electrical signal from the pulse generator to the vagus nerve to provide therapeutic effects for a neurostimulation therapy at an intensity that avoids physiological side effects; and

a controller configured to use stored parameters in a memory to deliver neurostimulation to the vagus nerve before detection of a precursor to a tachycardia, detect the precursor, and respond to the detected precursor by temporarily changing an intensity of the delivered neurostimulation.

13. The vagus nerve neurostimulator according to claim 12, further comprising a physiological sensor.

14. The vagus nerve neurostimulator according to claim 12, further comprising a heart rate sensor.

15. The vagus nerve neurostimulator of claim 12, further comprising an accelerometer.

16. The vagus nerve neurostimulator of claim 12, further comprising a minute ventilation sensor.

17. The vagus nerve neurostimulator according to claim 12, wherein the controller is configured to change the intensity of the electrical signal by changing a frequency of the electrical signal.

18. The vagus nerve neurostimulator according to claim 12, wherein the controller is configured change the intensity of the electrical signal by changing an amplitude of the electrical signal.

19. The vagus nerve neurostimulator according to claim 12, wherein the controller is configured to change the intensity of the electrical signal by changing a duty cycle of the electrical signal.

20. The vagus nerve neurostimulator according to claim 12, wherein the controller is configured to change the intensity of the electrical signal by changing a pulse width of the electrical signal.