Zirconium phosphate recharging method and apparatus

• US 10,343,145 B2
• Filed: 07/27/2018
• Issued: 07/09/2019
• Est. Priority Date: 11/26/2013
• Status: Active Grant

• Current Assignee: Mozarc Medical US LLC
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Pudil, Bryant J., Gerber, Martin T., Hobot, Christopher M.
• Primary Examiner(s): Gurtowski, Richard C
• Application Number:
  US16/047,245
• Publication Number:
  US 20190001303A1
• Time in Patent Office: 347 Days
• Field of Search: None
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: B01J 20/0211 Compounds of Ti, Zr, Hf
• CPC Class Codes: B01J 20/3475 in the liquid phase
• CPC Class Codes: B01J 20/3483 by thermal treatment not covered by groups B01J20/3441 - B01J20/3475, e.g. by heating or cooling
• CPC Class Codes: B01J 39/09 Inorganic material

Abstract

Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer or module of a sorbent material such as zirconium phosphate in a sorbent cartridge. The methods and apparatuses include a fluid source containing at least one recharging fluid, wherein the fluid source is fluidly connectable to at least one rechargeable sorbent module for use in sorbent dialysis in a fluid flow path. The methods and apparatuses include passing a single solution through the zirconium phosphate for ion exchanges, resulting in zirconium phosphate to maintain a substantially consistent pH in a dialysate used during dialysis.

Claims

1. A solution for recharging zirconium phosphate, comprising a combination of at least one sodium salt and at least one acid, the solution having a predetermined pH value that results in a substantially consistent pH in a dialysate passing through the zirconium phosphate after the solution is used for recharging zirconium phosphate.

2. The solution of claim 1, wherein the solution is selected from the group consisting of sodium acetate /acetic acid solution, glycolic/glycolate solution, citric/citrate solution, propionate/propionic solution, phosphate-monobasic solution, or any combination thereof.

3. The solution of claim 1, wherein the solution consists essentially of sodium chloride, sodium acetate and acetic acid.

4. The solution of claim 3, wherein concentrations of the sodium chloride, the sodium acetate, and the acetic acid are about 3.60M, 0.40M, and 0.40M, respectively, or about 3.88M, 0.12M, and 0.40M, respectively.

5. The solution of claim 3, wherein a concentration of acetic acid in the solution is greater than or equal to a concentration of sodium acetate in the solution.

6. The solution of claim 1, wherein the solution is a buffer solution.

7. The solution of claim 6, wherein the buffer solution has a pH of between any of about 4 and about 8, about 4.5 and about 6, about 6 and about 7, or about 5.5 and about 7.5.

8. The solution of claim 1, wherein the solution consists essentially of sodium chloride and sodium monobasic phosphate.

9. The solution of claim 8, wherein concentration of the sodium chloride is between about 3.20 M and about 4.0 M and wherein the concentration of the sodium monobasic phosphate is between about 0.05 M and about 0.8 M.

10. The solution of claim 8, wherein the pH of the solution is between any of about 2 and about 8, about 3 and about 5, about 3.5 and about 4.8, or about 4.0 and about 4.5.

11. The solution of claim 1, wherein the solution comprises glycolic acid.

12. The solution of claim 1, wherein the solution has a pH that results in a pH of between 5.9 and 6.9 in the dialysate passing through the zirconium phosphate after the solution is used for recharging zirconium phosphate.

13. The solution of claim 1, wherein the solution contains glycolic acid and sodium glycolate.

14. The solution of claim 1, wherein the solution contains citric acid and sodium citrate.

15. The solution of claim 1, wherein the solution contains propionic acid and sodium propionate.

16. A method of recharging zirconium phosphate in a rechargeable sorbent module, comprising the step of passing the solution of claim 1 through the rechargeable sorbent module.

17. The method of claim 16, wherein the solution is generated by mixing at least two different solutions in a recharger.

18. The method of claim 17, wherein the solution is generated by mixing an acetic acid solution, a sodium acetate solution, and a sodium chloride solution.

19. The method of claim 17, wherein the solution is generated by mixing an acetic acid solution, and a solution containing sodium acetate and sodium chloride.

20. The method of claim 16, further comprising the step of heating the solution prior to passing the solution through the rechargeable sorbent module.