PD-1 antibody, antigen-binding fragment thereof, and medical application thereof
First Claim
Patent Images
1. An anti-PD-1 antibody or an antigen-binding fragment thereof, comprising a light chain variable region comprising at least one of a LCDR1, a LCDR2 and a LCDR3 having the amino acid sequences of SEQ ID NO:
- 6, SEQ ID NO;
7 and SEQ ID NO;
8, respectively; and
a heavy chain variable region comprising a HCDR3 having the amino acid sequence of SEQ ID NO;
5.
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0 Petitions
Accused Products
Abstract
The present invention provides a human PD-1 antibody, an antigen-binding fragment thereof, and medical use thereof, and further provides a chimeric antibody and humanized antibodies comprising a complementarity-determining region (CDR) of the antibody, a pharmaceutical composition comprising the human PD-1 antibody and the antigen-binding fragment thereof, and use of the antibody in preparing medicines for treating diseases or disorders.
56 Citations
27 Claims
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1. An anti-PD-1 antibody or an antigen-binding fragment thereof, comprising a light chain variable region comprising at least one of a LCDR1, a LCDR2 and a LCDR3 having the amino acid sequences of SEQ ID NO:
- 6, SEQ ID NO;
7 and SEQ ID NO;
8, respectively; and
a heavy chain variable region comprising a HCDR3 having the amino acid sequence of SEQ ID NO;
5. - View Dependent Claims (2, 3, 4, 5, 6)
- 6, SEQ ID NO;
-
7. An anti-PD-1 antibody or an antigen-binding fragment thereof, comprising a light chain variable region comprising a LCDR1, a LCDR2 and a LCDR3 having the amino acid sequences of SEQ ID NO:
- 6, SEQ ID NO;
7 and SEQ ID NO;
8, respectively, and a heavy chain variable region comprising at least one of a HCDR1, a HCDR2 and a HCDR3 having the amino acid sequences of SEQ ID NO;
3, SEQ ID NO;
4 and SEQ ID NO;
5, respectively. - View Dependent Claims (8)
- 6, SEQ ID NO;
-
9. An anti-PD-1 antibody or an antigen-binding fragment thereof, comprising a light chain variable region comprising a LCDR1, a LCDR2 and a LCDR3 having the amino acid sequences of SEQ ID NO:
- 6, SEQ ID NO;
7 and SEQ ID NO;
8, respectively; and
a heavy chain variable region comprising a HCDR1, a HCDR2 and a HCDR3 having the amino acid sequences of SEQ ID NO;
3, SEQ ID NO;
4 and SEQ ID NO;
5, respectively. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- 6, SEQ ID NO;
Specification