Blood component measurement device and blood component measurement method

• US 10,344,312 B2
• Filed: 07/17/2017
• Issued: 07/09/2019
• Est. Priority Date: 07/08/2013
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: PHC Holdings Corporation
• Inventors: Fujiwara, Masaki, Yamamoto, Tomohiro
• Primary Examiner(s): Kosson, Rosanne
• Application Number:
  US15/651,640
• Publication Number:
  US 20180127795A1
• Time in Patent Office: 722 Days
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: C12Q 1/26 involving oxidoreductase
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771

Abstract

Provided are a blood component measurement device and the like capable of further suppressing the errors in measuring blood components. A first current value that is generated by oxidation-reduction when a first voltage is applied to a first electrode pair 21, 22 composing a biosensor 1 is measured, a second current value that is generated when a second voltage is applied to a second electrode pair 23, 24 composing the biosensor 1 is measured, and then the first current and the second current are converted to give a blood component amount. Within a predetermined period after the introduction of blood into the biosensor 1, the first current is measured multiple times and the second current is measured once. A CPU 72 converts a plurality of first current values and the second current value to obtain a plurality of blood component amounts and calculates the blood component amount for the blood introduced into the biosensor 1 from said plurality of blood component amounts.

Claims

1. A blood component measurement device that measures a blood component amount using a biosensor into which blood is introduced wherein the blood component contained in said blood is subjected to oxidation-reduction reaction using an oxidoreductase, wherein the blood component measurement device includes:

(a) a first current value measuring device that detects, as a first current value, an oxidation-reduction current that is generated by the oxidation-reduction reaction when a first voltage is applied to a first electrode pair in the biosensor;

(b) a second current value measuring device that detects, as a second current value, a current that is generated when a second voltage is applied to a second electrode pair in the biosensor;

(c) a controller that exerts control so that within a predetermined period after the introduction of the blood into the biosensor, the controller applies the second voltage to the second electrode pair in the form of pulses, so that the second current value is measured multiple times and the first current value is measured after the application of the second voltage;

(d) a converter that converts, to blood component amounts, pairs of the first current value measured by the first current value measuring device and any one of a plurality of second current values measured by the second current value measuring device; and

(e) a calculator that calculates the blood component amount for the blood introduced into the biosensor, using a plurality of the blood component amounts converted by the converter.

2. The blood component measurement device according to claim 1, wherein the blood component measurement device includes a memory that contains recorded data, stored per blood in which the blood component amount is known, including a plurality of the blood component amounts converted from the pairs of current values, and

wherein the calculator compares the recorded data with measured data including a plurality of the blood component amounts converted by the converter and calculates the blood component amount from recorded data closest to said measured data, as the blood component amount of the blood introduced into the biosensor.

3. The blood component measurement device according to claim 2, wherein the calculator compares a plurality of blood component amounts converted from arbitrary combinations of the first current value and the second current value selected from the pairs of current values measured as a result of the control exerted by the controller, with recorded data of a plurality of blood component amounts converted from the same combinations as the arbitrary combinations of the first current value and the second current value stored in the memory, and calculates the blood component amount from the closest recorded data, as the blood component amount of the blood introduced into the biosensor.

4. The blood component measurement device according to claim 1, wherein the blood component measurement device further includes:

(a) a memory that contains recorded data, stored per blood sample in which the blood component amount is known and per ambient temperature, including a plurality of the blood component amounts converted from the pairs of current values, and

(b) a temperature detector that detects the ambient temperature,

wherein the calculator (i) extracts a plurality of recorded data obtained at a temperature near the ambient temperature detected by the temperature detector, (ii) compares said plurality of recorded data thus extracted with measured data including the plurality of the blood component amounts converted by the converter, and (iii) calculates the blood component amount from the recorded data closest to said measured data, as the blood component amount of the blood introduced into the biosensor.