Pressure monitor optimization of fluid path utilization

• US 10,345,186 B2
• Filed: 08/18/2017
• Issued: 07/09/2019
• Est. Priority Date: 03/05/2004
• Status: Active Grant

• Current Assignee: Waters Technologies Corporation (Waters Corporation)
• Original Assignee: Waters Technologies Corporation (Waters Corporation)
• Inventors: Ciolkosz, Theodore D., Usowicz, James E., Beals, Peyton C., Keene, Russell
• Primary Examiner(s): Fitzgerald, John
• Assistant Examiner(s): Frank, Rodney T
• Application Number:
  US15/681,136
• Publication Number:
  US 20170343446A1
• Time in Patent Office: 690 Days
• Field of Search: 73 40
• CPC Class Codes: B01D 15/14 relating to the introduction of the feed to the apparatus
• CPC Class Codes: B01D 15/163 Pressure or speed conditioning
• CPC Class Codes: G01M 3/02 by using fluid or vacuum
• CPC Class Codes: G01N 11/00 Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
• CPC Class Codes: G01N 30/24 Automatic injection systems
• CPC Class Codes: G01N 30/32 of pressure or speed G01N30/36 takes precedence

Abstract

A device comprising a pressure monitor and a control means that receives a signal representing measured pressure at the pressure monitor and controls the controllable elements of a fluid system is utilized to monitor a fluid system for error conditions, to optimize operations and to diagnose the fluid system. By following a testing protocol that selectively enables parts of the system, the control means narrows the list of possible falling components. Comparing the measured pressure against normal pressures allows the device to identify error conditions. Determining the volume of fluid being transported and controlling the duration of the flow optimizes operation of the fluid system.

Claims

1. A method of determining viscosity of a fluid in a calibrated fluid system having a viscosity calibration factor, said fluid system comprising a controllable pressure source responsive to a pressure command signal to create a source pressure on said fluid, at least one fluid path section having an open end and a second end, and said controllable pressure source connected to said second end of said at least one fluid path section, said method comprising:

providing a device comprising;

a pressure monitor in fluid communication with a fluid in said calibrated fluid system, said pressure monitor generating a signal representative of a measured pressure;

a control means for receiving said signal representative of said measured pressure and for sending signals to said fluid system;

placing said pressure monitor in communication with said fluid in said at least one fluid path section at a known position on said fluid path section;

issuing a pressure command signal from said control means to said controllable pressure source to create said source pressure, said source pressure causing said fluid to flow; and

calculating a viscosity of said fluid using said measured pressure and said viscosity calibration factor.

2. The method of claim 1, further comprising:

providing said control means with a library having entries comprising sets of command signals and sets of normal pressure values;

comparing said measured pressures to said normal pressure values; and

reporting differences that exceed a preset threshold.

3. The method of claim 1, wherein the controllable pressure source includes a first wash syringe for flushing the fluid path section.

4. The method of claim 3, wherein the controllable pressure source includes a second wash syringe for flushing the fluid path section.

5. The method of claim 4, further comprising actuating a valve to select between the first and second wash syringes.

6. The method of claim 1, wherein the pressure command signal causes the fluid to flow such that a predetermined volume of fluid is delivered to the fluid path section.

7. The method of claim 1, wherein the step of calculating the viscosity of said fluid comprises using one of the following equation and any other algebraically equivalent equations to the following equation:

8. The method of claim 1, wherein said fluid system further comprises at least one valve having a plurality of ports for interconnecting with said at least one controllable pressure source and said at least one fluid path section, said valve being capable of assuming at least a first position wherein fluid flows between at least two of said plurality of ports in response to a connect command signal and a second position in which no fluid flows in response to a disconnect command signal, said valve is connected to an end of said fluid path section.

9. The method of claim 8, wherein said valve is a multiport valve.

10. The method of claim 1, wherein said fluid system is an autosampler for a liquid chromatography system.

11. A calibrated fluid system having a viscosity calibration factor, said fluid system comprising:

a controllable pressure source responsive to a pressure command signal to create a source pressure on a fluid;

at least one fluid path section having an open end and a second end, and said controllable pressure source connected to said second end of said at least one fluid path section; and

a device comprising;

a pressure monitor in fluid communication with said fluid in said calibrated fluid system at a known position on said fluid path section, said pressure monitor generating a signal representative of a measured pressure; and

a control means for receiving said signal representative of said measured pressure and for sending signals to said fluid system;

wherein said control means is configured to

issue a pressure command signal from said control means to said controllable pressure source to create said source pressure, said source pressure causing said fluid to flow; and

calculate a viscosity of said fluid using said measured pressure and said viscosity calibration factor.

12. The system of claim 11, wherein

said control means is provided with a library having entries comprising sets of command signals and sets of normal pressure values;

and

said control means is configured to;

compare said measured pressures to said normal pressure values, and

report differences that exceed a preset threshold.

13. The system of claim 11, further comprising a liquid chromatography system.

14. The system of claim 11, further comprising a liquid chromatography sample injection system.

15. The system of claim 11, further comprising at least one valve having a plurality of ports for interconnecting with said at least one controllable pressure source and said at least one fluid path section, said valve being capable of assuming at least a first position wherein fluid flows between at least two of said plurality of ports in response to a connect command signal and a second position in which no fluid flows in response to a disconnect command signal, said valve connected to an end of said fluid path section.

16. The system of claim 11, wherein the controllable pressure source includes a first wash syringe for flushing the fluid path.

17. The system of claim 16, wherein the controllable pressure source includes a second wash syringe for flushing the fluid path.

18. The system of claim 17, further comprising a valve configured to be actuated between the first and second wash syringes.

19. The system of claim 11, wherein the control means calculates the viscosity of said fluid using one of the following equation and any other algebraically equivalent equations to the following equation: