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Differential mobility spectrometry method

  • US 10,345,261 B2
  • Filed: 12/16/2015
  • Issued: 07/09/2019
  • Est. Priority Date: 12/31/2014
  • Status: Active Grant
First Claim
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1. A method of operating a system comprising a differential mobility spectrometer, the method comprising:

  • (a) injecting a stream of ions into a differential mobility spectrometer during a first duration, the stream of ions containing or suspected of containing an ion species of interest;

    (b) determining a compensation voltage apex for the ion species of interest in the differential mobility spectrometer, wherein the compensation voltage apex represents a nominal optimum for transmission of the ion species of interest based on operating conditions of the differential mobility spectrometer that are provided by a look-up table or wherein the compensation voltage apex for the ion species of interest is determined based on a theoretical optimum transmission compensation voltage;

    (c) varying the compensation voltage applied to the differential mobility spectrometer over a predetermined range about the determined compensation voltage apex during said first duration;

    (d) detecting the ion species of interest transmitted by the differential mobility spectrometer during said first duration and generating a composite spectra of the ion species of interest.

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