Magnetic switching

• US 10,349,870 B1
• Filed: 09/22/2015
• Issued: 07/16/2019
• Est. Priority Date: 09/22/2014
• Status: Active Grant

• Current Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Original Assignee: Verily Life Sciences LLC (Alphabet Inc.)
• Inventors: Demas, Vasiliki, Bajaj, Vikram Singh
• Primary Examiner(s): Winakur, Eric F
• Application Number:
  US14/861,822
• Time in Patent Office: 1,393 Days
• CPC Class Codes: A61B 2562/0223 Magnetic field sensors
• CPC Class Codes: A61B 5/02438 with portable devices, e.g. worn by the patient
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/6802 Sensor mounted on worn items
• CPC Class Codes: A61B 5/746 Alarms related to a physiological condition, e.g. details of setting alarm thresholds or avoiding false alarms alarms per se G08B
• CPC Class Codes: B03C 1/01 by addition of magnetic adjuvants
• CPC Class Codes: B03C 1/0332 using permanent magnets
• CPC Class Codes: B03C 1/0335 using coils
• CPC Class Codes: B03C 1/282 with associated accumulation indicator, e.g. Hall sensor
• CPC Class Codes: B03C 1/288 disposed at the outer circumference of a recipient
• CPC Class Codes: B03C 1/30 Combinations with other devices, not otherwise provided for
• CPC Class Codes: B03C 2201/18 Magnetic separation whereby the particles are suspended in a liquid
• CPC Class Codes: B03C 2201/22 characterised by the magnetic field, e.g. its shape or generation
• CPC Class Codes: B03C 2201/24 for measuring or calculating of parameters, e.g. efficiency
• CPC Class Codes: B03C 2201/26 for use in medical or biological applications
• CPC Class Codes: G01N 27/00 Investigating or analysing materials by the use of electric, electrochemical, or magnetic means G01N3/00 – G01N25/00 take precedence; measurement or testing of electric or magnetic variables or of electric or magnetic properties of materials G01R

Abstract

Methods of exerting magnetic forces to collect and manipulate magnetic particles disposed in a portion of subsurface vasculature using a wearable device are provided. The wearable device is configured to change the exerted magnetic force over time. For example, the exerted magnetic force could be sufficient to collect the magnetic particles during a first period of time and low enough to release the magnetic particles during a second period of time. The exerted magnetic force could be changed over time to vary some effect on the magnetic particles, for example to control a rate of release of collected magnetic particles. In some embodiments, the magnetic particles are configured to bind to an analyte of interest. The collection and manipulation of the magnetic particles can enable detection of one or more properties of the analyte, modification of the analyte, and/or extraction of the analyte bound to the magnetic particles.

Claims

1. A method, comprising:

positioning a device proximate to a biological environment that contains magnetic particles that are configured to selectively interact with an analyte of interest;

operating the device, during a first period of time, to collect, by way of exerting a first magnetic force, at least one of the magnetic particles in the biological environment, wherein the first magnetic force is an attractive magnetic force that is sufficient to collect the at least one of the magnetic particles in the biological environment proximate to the device; and

operating the device, during a second period of time, to exert a second magnetic force onto the magnetic particles in the biological environment, wherein the second magnetic force is different from the first magnetic force, and wherein the second magnetic force is sufficiently less than the first magnetic force that one or more of the magnetic particles collected proximate to the device during the first period of time are released during the second period of time;

wherein the device comprises a detector, and further comprising;

detecting one or more properties of the analyte of interest from the collected magnetic particles using the detector.

2. The method of claim 1, further comprising introducing the magnetic particles into the biological environment.

3. The method of claim 1, wherein the biological environment is a portion of subsurface vasculature proximate to an external body surface, and wherein positioning the device proximate to the biological environment comprises positioning the device on the external body surface.

4. The method of claim 1, wherein the device comprises at least one electromagnet, wherein operating the device during the first and second periods of time to exert first and second magnetic forces, respectively, comprises operating the at least one electromagnet of the device to exert the first and second magnetic forces on the magnetic particles.

5. The method of claim 1, wherein the device comprises at least one permanent magnet, wherein the first and second magnetic forces are caused by respective first and second magnetic fields produced by the at least one permanent magnet of the device during the first and second time periods, respectively.

6. The method of claim 5, further comprising moving the at least one permanent magnet of the device relative to the biological environment, wherein moving the at least one permanent magnet is performed between the first and second periods of time, wherein moving the at least one permanent magnet causes the second magnetic force to be less than the first magnetic force.

7. The method of claim 5, wherein the device further comprises a magnetic shim material, and further comprising:

moving the magnetic shim material relative to the at least one permanent magnet and the biological environment, wherein moving the magnetic shim material is performed between the first and second periods of time, wherein moving the magnetic shim material causes the second magnetic force to be less than the first magnetic force.

8. The method of claim 5, wherein the at least one permanent magnet comprises a plurality of permanent magnets, wherein individual permanent magnets of the plurality of permanent magnets have respective magnetic moments, wherein the magnetic moments of the plurality of permanent magnets have a first configuration during the first period of time and a second configuration during the second period of time such that the second magnetic force is less than the first magnetic force, and further comprising:

rotating the magnetic moments of at least two permanent magnets of the plurality of permanent magnets, wherein rotating the magnetic moments is performed between the first and second periods of time, and wherein rotating the magnetic moments causes the configuration of the magnetic moments of the plurality of permanent magnets to change between the first configuration and the second configuration.

9. The method of claim 1, further comprising:

extracting at least one of the collected at least one magnetic particle from the biological environment.

10. The method of claim 1, wherein the magnetic particles that are collected proximate to the device during the first period of time comprise a plug of magnetic particles, wherein the plug of magnetic particles has a rate of interaction with the analyte of interest that is related to the first and second magnetic forces such that the plug of magnetic particles has first and second rates of interaction during respective first and second periods of time, and wherein the second rate of interaction is higher than the first rate of interaction.

11. An apparatus, comprising:

a magnetic field producer, wherein the magnetic field producer is configured to be positioned proximate to an external body surface that is proximate to a portion of subsurface vasculature containing magnetic particles belonging to a specified set of magnetic particles, wherein the magnetic particles are configured to selectively interact with an analyte of interest, wherein the magnetic field producer is configured to exert first and second magnetic forces onto the magnetic particles during respective first and second periods of time, wherein the first magnetic force is an attractive magnetic force that is sufficient to collect, during the first period of time, at least one of the magnetic particles in the portion of subsurface vasculature proximate to the device, wherein the second magnetic force is different from the first magnetic force, and wherein the second magnetic force is sufficiently less than the first magnetic force that one or more of the magnetic particles collected proximate to the device during the first period of time are released during the second period of time, and

a detector configured to detect one or more properties of the analyte of interest from the collected particles.

12. The apparatus of claim 11, wherein the apparatus further comprises:

a mount configured to mount the magnetic field producer proximate to the external body surface.

13. The apparatus of claim 11, wherein the magnetic field producer comprises at least one permanent magnet.

14. The apparatus of claim 13, wherein the apparatus is configured to move the at least one permanent magnet relative to the portion of subsurface vasculature between the first period of time and the second period of time, wherein moving the at least one permanent magnet between the first period of time and the second period of time causes the second magnetic force to be less than the first magnetic force.

15. The apparatus of claim 13, further comprising a magnetic shim comprised of magnetic shim material, wherein the apparatus is configured to move the magnetic shim relative to the portion of subsurface vasculature between the first period of time and the second period of time, wherein moving the magnetic shim between the first period of time and the second period of time causes the second magnetic force to be less than the first magnetic force.

16. The apparatus of claim 13, wherein the at least one permanent magnet comprises a plurality of permanent magnets, wherein individual permanent magnets of the plurality of permanent magnets have respective magnetic moments, wherein the magnetic moments of the plurality of permanent magnets have a first configuration during the first period of time and a second configuration during the second period of time such that the second magnetic force is less than the first magnetic force, wherein the apparatus is configured to rotate the magnetic moments of at least two permanent magnets of the plurality of permanent magnets between the first period of time and the second period of time, and wherein rotating the magnetic moments between the first period of time and the second period of time causes the configuration of the magnetic moments of the plurality of permanent magnets to change between the first configuration and the second configuration.