Drug delivery implants

• US 10,349,993 B2
• Filed: 09/11/2017
• Issued: 07/16/2019
• Est. Priority Date: 08/13/2008
• Status: Active Grant

• Current Assignee: Smed-Ta/Td LLC
• Original Assignee: Smed-Ta/Td LLC
• Inventors: Nebosky, Paul S., Zimmerman, Sarah L., Stalcup, Gregory C.
• Primary Examiner(s): Sharma, Yashita
• Assistant Examiner(s): Preston, Rebecca S
• Application Number:
  US15/700,788
• Publication Number:
  US 20180021554A1
• Time in Patent Office: 673 Days
• CPC Class Codes: A61B 17/56 Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
• CPC Class Codes: A61B 17/60 for external osteosynthesis, e.g. distractors, contractors
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/7061 for stabilising vertebrae or discs by improving the condition of their tissues, e.g. using implanted medication or fluid exchange intraosseous injection devices A61B17/3472
• CPC Class Codes: A61B 17/7098 wherein the implant is permeable or has openings, e.g. fenestrated screw hollow surgical screws A61B17/864
• CPC Class Codes: A61B 17/80 Cortical plates , i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
• CPC Class Codes: A61B 17/846 Nails or pins, i.e. anchors without movable parts, holding by friction only, with or without structured surface A61B17/72, A61B17/86 take precedence
• CPC Class Codes: A61B 17/8625 Shanks, i.e. parts contacting bone tissue
• CPC Class Codes: A61B 17/864 hollow, e.g. with socket or cannulated
• CPC Class Codes: A61B 17/866 Material or manufacture
• CPC Class Codes: A61B 2017/561 Implants with special means for releasing a drug
• CPC Class Codes: A61C 8/0018 characterised by the shape
• CPC Class Codes: A61C 8/0039 in the form of hollow cylinder with an open bottom
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30 Joints
• CPC Class Codes: A61F 2/34 Acetabular cups
• CPC Class Codes: A61F 2/36 Femoral heads ; Femoral endoprostheses
• CPC Class Codes: A61F 2/3859 Femoral components
• CPC Class Codes: A61F 2/389 Tibial components A61F2/3868 takes precedence
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2002/30593 : hollow
• CPC Class Codes: A61F 2002/30672 : temporary
• CPC Class Codes: A61F 2002/30677 : Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/3068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2002/3071 : Identification means; Administration of patients
• CPC Class Codes: A61F 2002/30784 : Plurality of holes
• CPC Class Codes: A61F 2002/3092 : having an open-celled or open-pored structure
• CPC Class Codes: A61F 2250/0068 : the pharmaceutical product being in a reservoir
• CPC Class Codes: A61F 2250/0089 : coded with symbols, e.g. dots, numbers, letters, words
• CPC Class Codes: A61M 2210/02 : Bones
• CPC Class Codes: A61M 31/002 : Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 : specially adapted for implantation

Abstract

An orthopedic implant includes an internal fixation device. The internal fixation device includes: an exterior surface; a threaded section including a reservoir and at least one threaded section channel fluidly communicating the reservoir with the exterior surface, each threaded section channel having an interior diameter and a length which is greater than the interior diameter; a head including a head channel fluidly communicating the reservoir with an exterior surface of the head, a channel diameter of the head channel being respectively larger than a largest interior diameter of each threaded section channel, the channel diameter of the head channel being the same as a large interior diameter of the reservoir; and a continuously tapering inner surface between the head channel and the reservoir.

Claims

1. An orthopaedic implant, comprising:

an internal fixation device, said internal fixation device including;

an exterior surface;

a threaded section including a reservoir and at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said internal fixation device;

a head including a head channel fluidly communicating with said reservoir, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel, said channel diameter of said head channel being the same as a large interior diameter of said reservoir; and

a tapered region between and fluidly communicating said head channel and said reservoir, said tapered region defining a tapered diameter which is less than said channel diameter of said head channel.

2. The orthopaedic implant according to claim 1, wherein said reservoir is at least partially filled with at least one therapeutic agent and said at least one threaded section channel communicates said reservoir with said exterior surface of said internal fixation device and thereby conveys said at least one therapeutic agent from said reservoir to said exterior surface of said internal fixation device.

3. The orthopaedic implant according to claim 1, wherein said internal fixation device includes only one said reservoir.

4. The orthopaedic implant according to claim 1, wherein said reservoir is refillable.

5. The orthopaedic implant according to claim 1, wherein said internal fixation device comprises at least one of polyetheretherketone (PEEK), polyetherketone (PEK), polyaryletherketone (PAEK), polyethylene, polylactic acid (PLA), and polyglycolic acid (PGA).

6. The orthopaedic implant according to claim 1, wherein said threaded section includes at least one thread comprising at least one of a polymer, a reinforced polymer, and a metal.

7. The orthopaedic implant according to claim 1, further comprising a second reservoir in fluid communication with said reservoir.

8. The orthopaedic implant according to claim 7, wherein said second reservoir is in fluid communication with said reservoir via said head channel.

9. The orthopaedic implant according to claim 7, wherein said reservoir is at least partially filled with a first therapeutic agent and said second reservoir is at least partially filled with at least one of said first therapeutic agent and a second therapeutic agent different from said first therapeutic agent.

10. The orthopaedic implant according to claim 1, wherein said internal fixation device includes a plurality of threaded section channels including at least one threaded section channel on a first side of said reservoir and at least one threaded section channel on a second side of said reservoir opposite said first side.

11. The orthopaedic implant according to claim 1, wherein each threaded section channel has an interior diameter and a length which is greater than said interior diameter.

12. An orthopaedic implant, comprising:

an internal fixation device, said internal fixation device including;

an exterior surface;

a threaded section including a reservoir and at least one threaded section channel fluidly communicating said reservoir with said exterior surface of said internal fixation device;

a head including a head channel fluidly communicating with said reservoir, a channel diameter of said head channel being respectively larger than a largest interior diameter of each threaded section channel; and

a tapered region between and fluidly communicating said head channel and said reservoir, said tapered region defining a tapered diameter which is less than said channel diameter of said head channel, said tapered region defining a minimum diameter adjacent said head channel and a maximum diameter adjacent said reservoir.

13. The orthopaedic implant according to claim 12, wherein said reservoir is at least partially filled with at least one therapeutic agent and said at least one threaded section channel communicates said reservoir with said exterior surface of said internal fixation device and thereby conveys said at least one therapeutic agent from said reservoir to said exterior surface of said internal fixation device.

14. The orthopaedic implant according to claim 12, wherein said internal fixation device includes only one said reservoir.

15. The orthopaedic implant according to claim 12, wherein said threaded section includes at least one thread comprising at least one of a polymer, a reinforced polymer, and a metal.

16. The orthopaedic implant according to claim 12, further comprising a second reservoir in fluid communication with said reservoir.

17. The orthopaedic implant according to claim 16, wherein said second reservoir is in fluid communication with said reservoir via said head channel.

18. The orthopaedic implant according to claim 16, wherein said reservoir is at least partially filled with a first therapeutic agent and said second reservoir is at least partially filled with at least one of said first therapeutic agent and a second therapeutic agent different from said first therapeutic agent.

19. The orthopaedic implant according to claim 12, wherein said internal fixation device includes a plurality of threaded section channels including at least one threaded section channel on a first side of said reservoir and at least one threaded section channel on a second side of said reservoir opposite said first side.

20. The orthopaedic implant according to claim 12, wherein said channel diameter of said head channel is the same as a large interior diameter of said reservoir.