Antimicrobial gas impregnated devices and methods

• US 10,350,112 B2
• Filed: 06/29/2010
• Issued: 07/16/2019
• Est. Priority Date: 09/21/2007
• Status: Active Grant

• Current Assignee: Enox (Israel) LTD
• Original Assignee: Enox (Israel) LTD
• Inventors: Av-Gay, Yossef, Greenberg, David
• Primary Examiner(s): Farrar, Lauren P
• Application Number:
  US12/825,370
• Publication Number:
  US 20110076313A1
• Time in Patent Office: 3,304 Days
• CPC Class Codes: A61F 11/202 Surgical middle-ear ventilation or drainage, e.g. permanent; Implants therefor
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/45 Mixtures of two or more drugs, e.g. synergistic mixtures
• CPC Class Codes: A61L 2430/14 for ear reconstruction or ear implants, e.g. implantable hearing aids
• CPC Class Codes: A61L 31/04 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 27/002 Implant devices for drainage of body fluids from one part of the body to another intraocular A61F9/00781; middle ear A61F11/202
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 31/06 for tuberculosis

Abstract

A nitric oxide gas-releasing conduit configured for surgical implantation through a patient'"'"'s tympanic membrane. The nitric oxide gas-releasing conduit comprises a gas-permeable cured resin material configured for releasably sequestering therein gas. The gas-permeable cured resin material is charged with nitric oxide gas. The nitric oxide gas-releasing conduit may be optionally coated with an antimicrobial gas-releasing composition. The gas-releasing coating composition may be configured to release nitric oxide.

Claims

1. A container enclosing a device configured for insertion into a body, comprising:

a container that is impermeable to gaseous nitric oxide; and

a device configured for insertion into a body, said device consisting of a resin material permeable to gaseous nitric oxide, wherein the resin material is controllably saturated with gaseous nitric oxide so as to releasably sequester the nitric oxide gas molecules therein,

wherein said device with sequestered gaseous nitric oxide is packaged in said container impermeable to said gaseous nitric oxide.

2. The container of claim 1, wherein said resin material of said device is curable.

3. The container of claim 1, wherein said resin material of said device is microporous.

4. The container of claim 1, wherein said resin material of said device is hydrophobic.

5. The container of claim 1, wherein said resin material of said device is selected from the group consisting of curable silicones, polyvinyl acetates, thermoplastic elastomers, acrylonitrile-butadiene-styrene copolymer rubber, polyurethanes and selected combinations thereof.

6. The container of claim 1, wherein said resin material of said device is configured to be a conduit.