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Device and method for preventing hypoglicemia

  • US 10,350,354 B2
  • Filed: 06/20/2008
  • Issued: 07/16/2019
  • Est. Priority Date: 06/21/2007
  • Status: Active Grant
First Claim
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1. A method for glycemic control to prevent hypoglycemia during a fasting time period, comprising:

  • receiving a target blood glucose (TBG) level corresponding to a desired level of glucose in a patient'"'"'s body during the fasting time period;

    receiving a beginning blood glucose (BBG) level corresponding to a measured glucose level in the patient'"'"'s body substantially at a beginning of the fasting time period;

    receiving a first set of parameters comprising the patient'"'"'s insulin sensitivity (IS), the patient'"'"'s carbohydrate to insulin ratio (CIR), and the patient'"'"'s residual insulin (RI), said RI corresponding to a level of residual insulin in the patient'"'"'s body substantially at the beginning of the fasting time period;

    comparing the BBG level against the TBG level; and

    determining a therapeutic course of action including adjusting the patient'"'"'s basal rate (BR) based on the levels of the TBG, the BBG and the first set of parameters wherein the therapeutic course of action includes;

    (a) advising the patient to consume a calculated amount of carbohydrates (CC), with the calculated amount of carbohydrates (CC) being calculated in the following ways;

    (i) CC=CIR*(RI+((TBG−

    BBG)/IS)) when BBG<

    TBG and the RI>

    0,(ii) CC=(CIR*(TBG−

    BBG))/IS when BBG<

    TBG, and the RI is substantially negligible, and(iii) CC=CIR*(RI+((TBG−

    BBG)/IS)) when BBG>

    TBG and RI>

    (BBG−

    TBG)/IS, and(b) administering a correction bolus (CB) in the patient'"'"'s body, based upon (i) the comparison of the BBG level against the TBG level and (ii) the determined therapeutic course of action, with the correction bolus (CB) being calculated in the following ways;

    (i) CB=(BBG−

    TBG)/IS when BBG>

    TBG and there is substantially no RI, and(ii) CB=(BBG−

    TBG)/IS−

    RI when BBG>

    TBG and (BBG−

    TBG)/IS >

    RI.

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