Systems and methods for visualizing and directing stimulation of neural elements

• US 10,350,404 B2
• Filed: 08/29/2017
• Issued: 07/16/2019
• Est. Priority Date: 09/02/2016
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Zhang, Tianhe, Steinke, G. Karl, Mustakos, Richard
• Primary Examiner(s): Voorhees, Catherine M
• Application Number:
  US15/689,696
• Publication Number:
  US 20180064930A1
• Time in Patent Office: 686 Days
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

Method and systems for determining a set of stimulation parameters for an implantable stimulation device include receiving a set of stimulation parameters including at least one electrode for delivery of stimulation and a stimulation amplitude for each electrode; determining, using the set of stimulation parameters, an axial stimulation field for neural elements oriented axially with respect to a longitudinal axis of the lead; and outputting the first axial stimulation field for viewing by a user; receiving, by the computer processor. The methods and systems can be used to model other neural elements oriented non-orthogonally with respect to the longitudinal axis of the lead and determine a non-orthogonal stimulation field.

Claims

1. A computer-implemented method for determining a set of stimulation parameters for an electrical stimulation lead, the method comprising:

receiving, by a computer processor, a set of stimulation parameters comprising at least one electrode for delivery of stimulation and a stimulation amplitude for each of the at least one electrode;

determining, by the computer processor and using the set of stimulation parameters, a first axial stimulation field for neural elements oriented axially with respect to a longitudinal axis of the lead;

outputting, by the computer processor, the first axial stimulation field for viewing by a user;

receiving, by the computer processor, a modification of the set of stimulation parameters;

determining, by the computer processor and using the modified set of stimulation parameters, a second axial stimulation field for the neural elements oriented axially with respect to a longitudinal axis of the lead;

outputting, by the computer processor, the second axial stimulation field for viewing by a user;

receiving, by the computer processor, a user selection, in response to the output of the first axial stimulation field and the second axial stimulation field, of either the set of stimulation parameters, from which the first axial stimulation field was determined, or the modified set of stimulation parameters, from which the second axial stimulation field was determined, as a selected set of stimulation parameters; and

outputting, by the computer processor, the selected set of stimulation parameters to be received by an electrical stimulation device for delivery of electrical stimulation to a patient via an electrical stimulation lead.

2. The method of claim 1, wherein determining a first axial stimulation field comprises selecting a plurality of planes orthogonal to the lead;

modeling the neural elements as fixed length elements that intersect only one of the planes; and

determining, for each plane and using the stimulation parameters, which of the fixed length elements intersecting the plane are activated using the stimulation parameters.

3. The method of claim 1, wherein determining a first axial stimulation field comprises modeling the neural elements as extending axially relative to the lead;

and determining, using the stimulation parameters, which of the neural elements are activated using the stimulation parameters.

4. The method of claim 3, further comprising determining, by the computer processor, a time sequence of activation along the neural elements that are activated using the stimulation parameters and outputting, by the computer processor, the first axial stimulation field indicating different states of the first axial stimulation field over time based on the time sequence.

5. The method of claim 4, further comprising receiving, by the computer processor, a time selection and outputting, by the computer processor, the first axial stimulation field at the time selection based on the time sequence.

6. The method of claim 1, wherein determining a first axial stimulation field comprises modeling the neural elements as extending axially relative to the lead;

and determining, using the stimulation parameters, which of the neural elements are activated using the stimulation parameters and at what point along each of the neural elements that that neural element is first activated.

7. The method of claim 1, further comprising determining, by the computer processor and using the set of stimulation parameters, a first transverse stimulation field for neural elements oriented orthogonal with respect to a longitudinal axis of the lead;

and outputting, by the computer processor, the first transverse stimulation field for viewing by a user.

8. The method of claim 7, wherein outputting the first axial stimulation field and outputting the first transverse stimulation field comprises outputting the first axial stimulation field and first transverse stimulation field simultaneously.

9. The method of claim 8, further comprising receiving, by the computer processor, a user command to toggle either the first axial stimulation field or first transverse stimulation field either on or off.

10. The method of claim 1, wherein receiving a modification of the set of stimulation parameters comprises receiving a modified stimulation amplitude.

11. The method of claim 1, wherein receiving a modification of the set of stimulation parameters comprises receiving a modified selection of the at least one electrode for delivery of stimulation.

12. A system for determining a set of stimulation parameters for an electrical stimulation lead, the system comprising:

a display; and

a computer processor coupled to the display and configured and arranged to perform the method of claim 1.

13. The system of claim 12, further comprising an implantable lead and an implantable control module coupleable to the lead and configured and arranged to receive the set of stimulation parameters from the computer processor and to deliver electrical stimulation to a patient using the lead according to the set of stimulation parameters.

14. A non-transitory computer-readable medium having processor-executable instructions for determining a set of stimulation parameters, the processor-executable instructions when installed onto a device enable the device to perform actions, including:

receiving a set of stimulation parameters comprising at least one electrode for delivery of stimulation and a stimulation amplitude for each of the at least one electrode;

determining, using the set of stimulation parameters, a first axial stimulation field for neural elements oriented axially with respect to a longitudinal axis of the lead;

outputting the first axial stimulation field for viewing by a user;

receiving a modification of the set of stimulation parameters;

determining, using the modified set of stimulation parameters, a second axial stimulation field for the neural elements oriented axially with respect to a longitudinal axis of the lead;

outputting the second axial stimulation field for viewing by a user;

receiving a user selection, in response to the output of the first axial stimulation field and the second axial stimulation field, of either the set of stimulation parameters, from which the first axial stimulation field was determined, or the modified set of stimulation parameters, from which the second axial stimulation field was determined, as a selected set of stimulation parameters; and

outputting the selected set of stimulation parameters to be received by an electrical stimulation device for delivery of electrical stimulation to a patient via an electrical stimulation lead.

15. The non-transitory computer-readable medium of claim 14, wherein determining a first axial stimulation field comprises selecting a plurality of planes orthogonal to the lead;

modeling the neural elements as fixed length elements that intersect only one of the planes; and

determining, for each plane and using the stimulation parameters, which of the fixed length elements intersecting the plane are activated using the stimulation parameters.

16. The non-transitory computer-readable medium of claim 14, wherein determining a first axial stimulation field comprises modeling the neural elements as extending axially relative to the lead;

and determining, using the stimulation parameters, which of the neural elements are activated using the stimulation parameters.

17. A computer-implemented method for determining a set of stimulation parameters for an electrical stimulation lead, the method comprising:

receiving, by a computer processor, a set of stimulation parameters comprising at least one electrode for delivery of stimulation and a stimulation amplitude for each of the at least one electrode;

determining, by the computer processor and using the set of stimulation parameters, a first non-orthogonal stimulation field for neural elements oriented non-orthogonally with respect to a longitudinal axis of the lead at a specified non-orthogonal angle or over a specified range of non-orthogonal angles;

outputting, by the computer processor, the first non-orthogonal stimulation field for viewing by a user;

receiving, by the computer processor, a modification of the set of stimulation parameters;

determining, by the computer processor and using the modified set of stimulation parameters, a second non-orthogonal stimulation field for the neural elements oriented non-orthogonally with respect to a longitudinal axis of the lead;

outputting, by the computer processor, the second non-orthogonal stimulation field for viewing by a user;

receiving, by the computer processor, a user selection, in response to the output of the first non-orthogonal stimulation field and the second non-orthogonal stimulation field, of either the set of stimulation parameters, from which the first non-orthogonal stimulation field was determined, or the modified set of stimulation parameters, from which the second non-orthogonal stimulation field was determined, as a selected set of stimulation parameters; and

outputting, by the computer processor, the selected set of stimulation parameters to be received by an electrical stimulation device for delivery of electrical stimulation to a patient via an electrical stimulation lead.

18. The method of claim 17, wherein determining a first non-orthogonal stimulation field comprises selecting a plurality of planes orthogonal to the lead;

modeling the neural elements as fixed length elements that intersect only one of the planes; and

determining, for each plane and using the stimulation parameters, which of the fixed length elements intersecting the plane are activated using the stimulation parameters.

19. The method of claim 17, wherein determining a first non-orthogonal stimulation field comprises modeling the neural elements as extending non-orthogonally relative to the lead;

and determining, using the stimulation parameters, which of the neural elements are activated using the stimulation parameters.

20. The method of claim 19, further comprising determining, by the computer processor, a time sequence of activation along the neural elements that are activated using the stimulation parameters and outputting, by the computer processor, the first non-orthogonal stimulation field indicating different states of the first non-orthogonal stimulation field over time based on the time sequence.