Protein activity modification
First Claim
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1. A method for classifying a patient according to an expected responsiveness to a non-excitatory electric field treatment using an extracted heart tissue sample, comprising:
- applying a non-excitatory electric field to an extracted heart tissue sample;
testing expression markers of a plurality of proteins in said tissue sample, after said applying, to obtain results of said testing, at least one of said plurality of proteins being an HF-related protein; and
classifying the suitability of said patient for a non-excitatory electric field treatment based on said results for a plurality of proteins expression markers.
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Abstract
A method of modifying tissue behavior, comprising:
- determining a desired modification of tissue behavior for at least one of treatment of a disease, short or long term modification of tissue behavior, assessing tissue state and assessing tissue response to stimulation;
- selecting an electric field having an expected effect of modifying protein activity of at least one protein as an immediate response of a tissue to the field, said expected effect correlated with said desired modification; and
- applying said field to said tissue.
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Citations
21 Claims
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1. A method for classifying a patient according to an expected responsiveness to a non-excitatory electric field treatment using an extracted heart tissue sample, comprising:
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applying a non-excitatory electric field to an extracted heart tissue sample;
testing expression markers of a plurality of proteins in said tissue sample, after said applying, to obtain results of said testing, at least one of said plurality of proteins being an HF-related protein; andclassifying the suitability of said patient for a non-excitatory electric field treatment based on said results for a plurality of proteins expression markers. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A kit for classifying a patient according to an expected responsiveness to a non-excitatory electric field treatment using an extracted heart tissue sample, said kit comprising:
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(a) a sample chamber configured for use outside the body; (b) at least one electrode configured to apply an electric field to tissue within the sample chamber; (c) a stimulator for applying to said electrode an electric field suitable for a non-excitatory stimulation of an extracted tissue sample within the sample chamber; and (d) a plurality of indicators for a plurality of proteins expression markers, at least one of said plurality of proteins is an HF-related protein. - View Dependent Claims (16, 17, 18, 19, 20)
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21. A method for determining the suitability of a treatment to a patient, according to an expected responsiveness to a non-excitatory electric field treatment using an extracted heart tissue sample, comprising:
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applying a non-excitatory electric field to an extracted heart tissue sample; testing expression markers of a plurality of proteins in said tissue sample, after said applying, to obtain results of said testing, at least one of said plurality of proteins being an HF-related protein; and selecting a non-excitatory electric field treatment expected to have a therapeutic effect on said patient based on said results for a plurality of proteins expression markers.
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Specification