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Sensors for assaying coagulation in fluid samples

  • US 10,352,951 B2
  • Filed: 01/25/2018
  • Issued: 07/16/2019
  • Est. Priority Date: 09/26/2014
  • Status: Active Grant
First Claim
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1. A method for performing one or more diagnostic clotting time tests on a blood sample, the method comprising:

  • providing one or more sensors for performing the diagnostic clotting time tests, wherein each of the one or more sensors comprises at least one transducer coated with a polymer layer, wherein the polymer layer is a porous support layer that comprises immobilized therein a thrombin-cleavable peptide, wherein the thrombin-cleavable peptide comprises a detectable moiety linked by a thrombin-cleavable amide bond to a polypeptide sequence that is non-reactive with blood proteases other than thrombin;

    contacting the blood sample with one or more reagents for performing the one or more diagnostic clotting time tests;

    contacting the blood sample with the one or more sensors; and

    determining the one or more diagnostic clotting times using at least the one or more sensors.

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