Image processing method for determining patient-specific cardiovascular information

• US 10,354,050 B2
• Filed: 06/29/2016
• Issued: 07/16/2019
• Est. Priority Date: 03/17/2009
• Status: Active Grant

• Current Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Original Assignee: Board of Trustees of the Leland Stanford Junior University (Stanford University)
• Inventors: Taylor, Charles A., Kim, Hyun Jin, Coogan, Jessica S.
• Primary Examiner(s): Clow, Lori A.
• Application Number:
  US15/196,836
• Publication Number:
  US 20160378947A1
• Time in Patent Office: 1,112 Days
• Field of Search: None
• CPC Class Codes: G06T 19/00 Manipulating 3D models or images for computer graphics
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 30/00 ICT specially adapted for the handling or processing of medical images computed tomography A61B6/03
• CPC Class Codes: G16H 30/20 for handling medical images, e.g. DICOM, HL7 or PACS
• CPC Class Codes: G16H 30/40 for processing medical images, e.g. editing
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders

Abstract

A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.

Claims

1. A method for determining cardiovascular information for a patient, the method comprising:

receiving, using at least one computer system, patient-specific data of at least a first portion of a coronary artery of a patient'"'"'s heart;

generating, using the at least one computer system, a patient-specific geometric model of a geometry of the first portion of the patient'"'"'s coronary artery, the patient-specific geometric model being generated based on the received patient-specific data;

generating, using the at least one computer system, a lower-order patient-specific model of blood flow through a second portion of the patient'"'"'s coronary artery downstream from the first portion, the lower-order patient-specific model having fewer dimensions than the patient-specific geometric model, the lower-order patient-specific model comprising one or more fluid dynamics equations and one or more blood flow parameters associated with blood flow through the second portion of the patient'"'"'s coronary artery downstream from the first portion;

determining, using the at least one computer system, fluid dynamics equations governing blood flow through the patient-specific geometric model of the geometry of the first portion of the patient'"'"'s coronary artery; and

calculating, using the at least one computer system, a value of a characteristic of blood flow through the first portion of the patient'"'"'s coronary artery by implicit closed-loop coupling and simultaneous solving of both the fluid dynamics equations governing blood flow through the patient-specific geometric model and the fluid dynamics equations governing blood flow of the lower-order patient-specific model of blood flow through the second portion.

2. The method of claim 1, wherein the patient-specific geometric model comprises a three-dimensional model.

3. The method of claim 1, wherein the lower-order patient-specific model of blood flow comprises a lumped parameter model.

4. The method of claim 1, wherein the lower-order patient-specific model of blood flow comprises a lumped parameter heart model, a lumped parameter systemic vascular model, a lumped parameter pulmonary vascular model, or any combination thereof.

5. The method of claim 1, wherein the characteristic of blood flow comprises a coronary blood flow rate and/or coronary blood pressure.

6. A system for determining cardiovascular information for a patient, the system comprising:

a data storage device storing instructions for performing a method of determining cardiovascular information for a patient; and

a processor configured to execute the instructions including;

receiving, using at least one computer system, patient-specific data of at least a first portion of a coronary artery of a patient'"'"'s heart;

generating, using the at least one computer system, a patient-specific geometric model of a geometry of the first portion of the patient'"'"'s coronary artery, the patient-specific geometric model being generated based on the received patient-specific data;

generating, using the at least one computer system, a lower-order patient-specific model of blood flow through a second portion of the patient'"'"'s coronary artery downstream from the first portion, the lower-order patient-specific model having fewer dimensions than the patient-specific geometric model, the lower-order patient-specific model comprising one or more fluid dynamics equations and one or more blood flow parameters associated with blood flow through the second portion of the patient'"'"'s coronary artery downstream from the first portion;

determining, using the at least one computer system, fluid dynamics equations governing blood flow through the patient-specific geometric model of the geometry of the first portion of the patient'"'"'s coronary artery; and

calculating, using the at least one computer system, a value of a characteristic of blood flow through the first portion of the patient'"'"'s coronary artery by implicit closed-loop coupling and simultaneous solving of both the fluid dynamics equations governing blood flow through the patient-specific geometric model and the fluid dynamics equations governing blood flow of the lower-order patient-specific model of blood flow through the second portion.

7. The system of claim 6, wherein the patient-specific geometric model comprises a three-dimensional model.

8. The system of claim 6, wherein the lower-order patient-specific model of blood flow comprises a lumped parameter model.

9. The system of claim 6, wherein the lower-order patient-specific model of blood flow comprises a lumped parameter heart model, a lumped parameter systemic vascular model, a lumped parameter pulmonary vascular model, or any combination thereof.

10. The system of claim 6, wherein the characteristic of blood flow comprises a coronary blood flow rate and/or coronary blood pressure.

11. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of determining cardiovascular information for a patient, the method comprising:

receiving, using at least one computer system, patient-specific data of at least a first portion of a coronary artery of a patient'"'"'s heart;

generating, using the at least one computer system, a patient-specific geometric model of a geometry of the first portion of the patient'"'"'s coronary artery, the patient-specific geometric model being generated based on the received patient-specific data;

generating, using the at least one computer system, a lower-order patient-specific model of blood flow through a second portion of the patient'"'"'s coronary artery downstream from the first portion, the lower-order patient-specific model having fewer dimensions than the patient-specific geometric model, the lower-order patient-specific model comprising one or more fluid dynamics equations and one or more blood flow parameters associated with blood flow through the second portion of the patient'"'"'s coronary artery downstream from the first portion;

determining, using the at least one computer system, fluid dynamics equations governing blood flow through the patient-specific geometric model of the geometry of the first portion of the patient'"'"'s coronary artery; and

calculating, using the at least one computer system, a value of a characteristic of blood flow through the first portion of the patient'"'"'s coronary artery by implicit closed-loop coupling and simultaneous solving of both the fluid dynamics equations governing blood flow through the patient-specific geometric model and the fluid dynamics equations governing blood flow of the lower-order patient-specific model of blood flow through the second portion.

12. The computer readable medium of claim 11, wherein the patient-specific geometric model comprises a three-dimensional model.

13. The computer readable medium of claim 11, wherein the lower-order patient-specific model of blood flow comprises a lumped parameter model.

14. The computer readable medium of claim 11, wherein the characteristic of blood flow comprises a coronary blood flow rate and/or coronary blood pressure.