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Statistical mapping in an optoacoustic imaging system

  • US 10,354,379 B2
  • Filed: 11/06/2017
  • Issued: 07/16/2019
  • Est. Priority Date: 03/09/2012
  • Status: Active Grant
First Claim
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1. A method to produce an image of a tissue comprising:

  • receiving acoustic return signals generated by energy transmitted into the tissue;

    determining from the acoustic return signals a parametric map of values of a first parameter by computing;

    i) a first spatial representation of the tissue based on acoustic return signals associated with a first predominant wavelength and ii) a second spatial representation of the tissue based on acoustic return signals associated with a second predominant wavelength;

    normalizing at least one of the first and second spatial representations in a region of interest in the parametric map using a scalar projection of values in the region of interest for the first wavelength onto values in the region of interest for the second wavelength, wherein normalizing comprises multiplying at least one of the first and second spatial representations in proportion to the result of the scalar projection;

    producing a mapping configuration to compensate for effects caused by a variability in the transmitted energy by;

    i) determining a first reference level within the region of interest; and

    ii) specifying an upper color map limit and a lower color map limit, at least one of the upper color map limit or the lower color map limit determined in relation to the first reference level; and

    rendering the parametric map in the palette of a color map by mapping the values of the parametric map onto the color map according to the upper and lower color map limits of the mapping configuration to produce a rendered parametric map.

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