Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
First Claim
1. A composition for treating channelopathies or a cardiopathy caused by the administration of one or more drugs in a human or animal subject consisting of:
- a combination of one or more pharmacologically active agents that cause a cardiopathy in the subject; and
one or more empty liposomes administered prior to, concomitantly, or after administration of the pharmacologically active agent effective to reduce or eliminate the cardiopathy caused by the active agent, wherein the composition is dispersed in a pharmaceutically acceptable medium and the cardiopathy is selected from long QT syndrome (LQTS), atrial flutter, atrial fibrillation, ventricular tachycardia, sinus bradycardia, sinus tachycardia, atrial tachycardia, atrial fibrillation, atrial flutter, atrioventricular nodal block, atrioventricular node reentry tachycardia, atrioventricular reciprocating tachycardia, ventricular tachycardia, ventricular fibrillation, or any combinations thereof wherein the one or more active agents consists of Aloxi or palonasitron HCL, Amiodarone, Arsenic trioxide, Astemizole, Bepridil, Chloroquine-Chlorpheniramine, Chlorpromazine, Cisapride, Celaxa, Clarithromycin, Erythromycin, Curcumin, Disopyramide, Dofetilide, Domperidone, Doxorubicin, Dronedarone, Droperidol, Grepafloxacin, Haldol, Haloperidol, Halofantrine, Ibutilide, Levomethadyl, Lidoflazine, Loratidine, Lovostatin, Mesoridazone, Methadone, Methanesulphonanilide (E-4031), Moxifloxacin, Pentamadine, Pimozide, Prenylamine, Probucol, Procainamide, Propafenone, Pyrilamine, Quinidine, Terfenidine, Sertindole, Sotalol, Sparfloxacin, or Thioridazine.
1 Assignment
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Accused Products
Abstract
Compositions and methods for the treatment of drug-induced long QT syndrome and other cardiac channelopathies are disclosed herein. The compositions and methods of the present invention comprise binding one or more QT prolonging drugs with a liposome prior to parenteral (intravenous or subcutaneous) administration, or administration of an empty liposome prior to or concomitantly with therapeutic agents known to have a high risk of QT prolongation, or immediately following an envenomation. The results presented show an abrogation of the adverse effects of QT prolonging drugs in a dose-dependent manner by the compositions of the present invention.
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Citations
12 Claims
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1. A composition for treating channelopathies or a cardiopathy caused by the administration of one or more drugs in a human or animal subject consisting of:
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a combination of one or more pharmacologically active agents that cause a cardiopathy in the subject; and one or more empty liposomes administered prior to, concomitantly, or after administration of the pharmacologically active agent effective to reduce or eliminate the cardiopathy caused by the active agent, wherein the composition is dispersed in a pharmaceutically acceptable medium and the cardiopathy is selected from long QT syndrome (LQTS), atrial flutter, atrial fibrillation, ventricular tachycardia, sinus bradycardia, sinus tachycardia, atrial tachycardia, atrial fibrillation, atrial flutter, atrioventricular nodal block, atrioventricular node reentry tachycardia, atrioventricular reciprocating tachycardia, ventricular tachycardia, ventricular fibrillation, or any combinations thereof wherein the one or more active agents consists of Aloxi or palonasitron HCL, Amiodarone, Arsenic trioxide, Astemizole, Bepridil, Chloroquine-Chlorpheniramine, Chlorpromazine, Cisapride, Celaxa, Clarithromycin, Erythromycin, Curcumin, Disopyramide, Dofetilide, Domperidone, Doxorubicin, Dronedarone, Droperidol, Grepafloxacin, Haldol, Haloperidol, Halofantrine, Ibutilide, Levomethadyl, Lidoflazine, Loratidine, Lovostatin, Mesoridazone, Methadone, Methanesulphonanilide (E-4031), Moxifloxacin, Pentamadine, Pimozide, Prenylamine, Probucol, Procainamide, Propafenone, Pyrilamine, Quinidine, Terfenidine, Sertindole, Sotalol, Sparfloxacin, or Thioridazine. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A composition for treating a cardiopathy in a human or animal subject consisting of:
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a therapeutically active agent or a drug that causes a cardiopathy; and one or more liposomes administered prior to, concomitantly, or after administration of the therapeutically active agent or the drug effective to reduce the cardiopathy caused by the one or more drugs, wherein the composition is dispersed in a pharmaceutically acceptable medium and the therapeutically active agent or a drug is not encapsulated by the liposomes, and wherein the cardiopathy is selected from the group consisting of long QT syndrome (LQTS), atrial flutter, atrial fibrillation, ventricular tachycardia, sinus bradycardia, sinus tachycardia, atrial tachycardia, atrial fibrillation, atrial flutter, atrioventricular nodal block, atrioventricular node reentry tachycardia, atrioventricular reciprocating tachycardia, ventricular tachycardia, ventricular fibrillation, or any combinations thereof and wherein the therapeutically active agent or drug consists of Aloxi or palonasitron HCl, Amiodarone, Arsenic trioxide, Astemizole, Bepridil, Chloroquine-Chlorpheniramine, Chlorpromazine, Cisapride, Celaxa, Clarithromycin, Erythromycin, Disopyramide, Dofetilide, Domperidone, Doxorubicin, Dronedarone, Droperidol, Grepafloxacin, Haldol, Haloperidol, Halofantrine, Ibutilide, Levomethadyl, Lidoflazine, Loratidine, Lovostatin, Mesoridazone, Methadone, Methanesulphonanilide (E-4031), Moxifloxacin, Pentamadine, Pimozide, Prenylamine, Probucol, Procainamide, Propafenone, Pyrilamine, Quinidine, Terfenidine, Sertindole, Sotalol, Sparfloxacin, or Thioridazine. - View Dependent Claims (9, 10, 11, 12)
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Specification