Medicaments for slowing Parkinson's disease
First Claim
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1. A method of slowing progression of Parkinson'"'"'s Disease which comprises administering to a patient not previously treated with a COMT inhibitor an effective amount of:
- (i) levodopa;
(ii) an AADC inhibitor; and
(iii) opicapone, wherein the dose of opicapone is 15 mg to 100 mg once per day;
wherein the patient not previously treated with a COMT inhibitor refers to a patient(1) experiencing a mean daily OFF time of up to 6 hours;
(2) having a PD diagnosis for up to 8 years;
(3) experiencing motor symptoms and/or motor complications for up to 4 years;
or(4) taking an average daily dose of levodopa of up to 800 mg.
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Abstract
Opicapone, levodopa and an AADC inhibitor are described for use in slowing the progression of Parkinson'"'"'s Disease.
78 Citations
21 Claims
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1. A method of slowing progression of Parkinson'"'"'s Disease which comprises administering to a patient not previously treated with a COMT inhibitor an effective amount of:
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(i) levodopa; (ii) an AADC inhibitor; and (iii) opicapone, wherein the dose of opicapone is 15 mg to 100 mg once per day; wherein the patient not previously treated with a COMT inhibitor refers to a patient (1) experiencing a mean daily OFF time of up to 6 hours; (2) having a PD diagnosis for up to 8 years; (3) experiencing motor symptoms and/or motor complications for up to 4 years;
or(4) taking an average daily dose of levodopa of up to 800 mg. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of delaying progression of Parkinson'"'"'s Disease in patients treated with an effective dose of levodopa and an AADC inhibitor which comprises administering an effective dose of opicapone to said patient,
wherein the dose of opicapone is 15 mg to 100 mg once per day; wherein the patient refers to a patient (1) experiencing a mean daily OFF time of up to 6 hours; (2) having a PD diagnosis for up to 8 years; (3) experiencing motor symptoms and/or motor complications for up to 4 years;
or(4) taking an average daily dose of levodopa of up to 800 mg. - View Dependent Claims (17, 18, 19, 20, 21)
Specification