Method for the management of cancer and cancer treatment-related comorbidities

• US 10,357,531 B2
• Filed: 11/07/2014
• Issued: 07/23/2019
• Est. Priority Date: 11/08/2013
• Status: Active Grant

• Current Assignee: Legacy HealthCare (Switzerland) SA
• Original Assignee: Legacy Healthcare Ltd.
• Inventors: Harti, Saad, Liu, JiaWei
• Primary Examiner(s): Hoffman, Susan
• Application Number:
  US15/032,179
• Publication Number:
  US 20160256512A1
• Time in Patent Office: 1,719 Days
• Field of Search: None
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 36/18 Magnoliophyta (angiosperms)
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/752 Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/77 Sapindaceae (Soapberry family), e.g. lychee or soapberry
• CPC Class Codes: A61K 36/88 Liliopsida (monocotyledons)
• CPC Class Codes: A61K 36/8962 Allium, e.g. garden onion, leek, garlic or chives
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 7/06 Antianaemics

Abstract

A method for the management of cancer and treatment of cancer comorbidities, including but not limited to cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, skin, and skin appendages adverse reactions; the method including the administration by the conventional and non-conventional oral, topical, parenteral routes and intra-tumoral injection, or in combination thereof, or the administration as adjuvant potentiator in other therapies using the forenamed routes, of a composition containing as active ingredient an extract of Allium species, which contains querceting, an extract of Citrus species and an extract of Paullinia species and an extract of Theobroma species.

Claims

1. A method for management of cancer and for treatment of cancer-related fatigue in a subject in need thereof, the method comprising:

administering to the subject, by an oral route, a topical route, a parenteral route, an intra-tumoral injection, or a combination thereof, a composition comprising as an active ingredient an extract of Allium species comprising quercetin, an extract of Citrus species, an extract of Paullinia species and an extract of Theobroma species.

2. A method for the management of the cancer and for the treatment of cancer-related fatigue according to claim 1, wherein the composition contains the extract of the Allium species comprising quercetin, the extract of the Citrus species, an atomized extract of the Paullinia species and an atomized extract of the Theobroma species.

3. A method for the management of the cancer and for the treatment cancer-related fatigue according to claim 1, wherein the composition comprises:

from 30% to 93% by weight of the extract of the Allium species comprising quercetin, from 3% to 33% by weight of the extract of the Citrus species, from 0.10% to 2.5% by weight of the extract of the Pauffinia species, and from 0.10% to 2.5% by weight of the extract of the Theobroma species, based on the total weight of the four active ingredients.

4. A method for management of cancer and for treatment of cancer-related fatigue in a subject in need thereof, the method comprising:

administering to the subject, by an oral route, a topical route, a parenteral route, an intra-tumoral injection, or a combination thereof, a composition consisting of an extract of Allium species comprising quercetin, an extract of Citrus species, an extract of Pauffinia species, and an extract of Theobroma species.