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Cyclotides as immunosuppressive agents

  • US 10,357,537 B2
  • Filed: 10/30/2018
  • Issued: 07/23/2019
  • Est. Priority Date: 12/22/2011
  • Status: Active Grant
First Claim
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1. Method of screening for and/or selecting an immunosuppressive cyclotide, the method comprising:

  • (i) contacting activated immune cells with a cyclotide or a plant extract containing a cyclotide and determining the proliferative activity of said activated immune cells,wherein a reduced proliferative activity as compared to a control is indicative for the immunosuppressive activity of the cyclotide or plant extract containing a cyclotide;

    or(ii) administering to an animal model a pharmaceutically effective amount of a cyclotide or a plant extract containing a cyclotide and determining one or more parameters of the immune system,wherein the reduction of the one or more parameters of the immune system as compared to a control is indicative for the immunosuppressive activity of the cyclotide or plant extract containing a cyclotide.

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