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Mapping transcranial signals to transcranial stimulation required to reproduce a brain state

  • US 10,357,654 B1
  • Filed: 10/28/2016
  • Issued: 07/23/2019
  • Est. Priority Date: 08/27/2015
  • Status: Active Grant
First Claim
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1. A system for computing a transcranial stimulation montage, the system comprising:

  • one or more processors and a memory, the memory being a non-transitory computer-readable medium having executable instructions encoded thereon, such that upon execution of the instructions, the one or more processors perform operations of;

    mapping externally sensed brain activity data representing a first brain state to voxels of brain volume;

    mapping externally sensed brain activity data representing a second brain state to voxels of brain volume;

    translating a brain activity change from the second brain state to the first brain state in each relevant voxel of the brain into a necessary electrical field based on diffusion tensor imaging (DTI) data,wherein the DTI imaging data provides an average white matter tract orientation in each relevant voxel, and wherein the translated brain activity change in each relevant voxel is translated into the necessary electrical field by aligning to the average white matter tract orientation in each relevant voxel;

    computing an electrical stimulation montage from the translated brain activity change; and

    controlling application of the electrical stimulation montage by transcranial stimulation electrodes to transform the second brain state into the first brain state, the electrical stimulation montage including the necessary electrical field.

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