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Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene

  • US 10,358,646 B2
  • Filed: 11/05/2014
  • Issued: 07/23/2019
  • Est. Priority Date: 12/04/2008
  • Status: Active Grant
First Claim
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1. A method of upregulating a function of and/or the expression of a PTEN Tumor Suppressor gene polynucleotide in patient cells or tissues in vivo or in vitro comprising:

  • contacting said cells or tissues with at least one single-stranded antisense oligonucleotide of 15 to 30 nucleotides in length that targets, is 100% complementary to and specifically hybridizes to a complementary region of a natural antisense polynucleotide of a Tumor Suppressor gene polynucleotide selected from the group consisting of nucleotides 1-189 of SEQ ID NO;

    14 and nucleotides 1-467 of SEQ ID NO;

    15;

    thereby upregulating a function of and/or the expression of the Tumor Suppressor gene polynucleotide in patient cells or tissues in vivo or in vitro.

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