System and method for tissue differentiation in imaging
First Claim
Patent Images
1. A method of assessing a degree of differentiation for a second region of an OCT image of a tissue sample with respect to a first region, wherein the method comprises:
- receiving OCT image data for the OCT image, the OCT image being a 3D OCT image comprising a plurality of B-scan images;
identifying a boundary in the OCT image to identify the second region in the OCT image, the second region being disposed below the boundary;
identifying a first set of OCT image data corresponding to the first region and a second set of OCT image data corresponding to the second region;
generating a first optical dataset based on measurements of at least one first optical characteristic for the first set of OCT image data;
generating a second optical dataset based on measurements of the at least one first optical characteristic for the second set of OCT image data;
determining a margin width in B-scan data for the OCT image, the margin width corresponding to a shortest distance between the boundary and a surface of the tissue sample;
determining when the margin width is less than a margin threshold;
receiving a known optical dataset generated based on measurements of the at least one first optical characteristic for a known set of OCT image data corresponding to a known region in a stored OCT image; and
determining a discrimination score based on the second optical dataset and the known optical dataset to indicate a degree of difference between the second region and the known region and comparing the discrimination score to a predefined threshold to identify a high degree of difference between the second region and the known region which indicates that the second and known region comprise different tissue types.
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Abstract
Various embodiments of systems and methods are described herein for obtaining wide field OCT images and other types of image data from at least one portion of a sample. Various embodiments of systems, and methods are described herein for assessing a degree of differentiation for a second region of an OCT image of a tissue sample with respect to another first. Various embodiments of a sample container are also described herein for containing a tissue sample and maintaining the tissue sample in a defined orientation during imaging or handling.
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Citations
20 Claims
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1. A method of assessing a degree of differentiation for a second region of an OCT image of a tissue sample with respect to a first region, wherein the method comprises:
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receiving OCT image data for the OCT image, the OCT image being a 3D OCT image comprising a plurality of B-scan images; identifying a boundary in the OCT image to identify the second region in the OCT image, the second region being disposed below the boundary; identifying a first set of OCT image data corresponding to the first region and a second set of OCT image data corresponding to the second region; generating a first optical dataset based on measurements of at least one first optical characteristic for the first set of OCT image data; generating a second optical dataset based on measurements of the at least one first optical characteristic for the second set of OCT image data; determining a margin width in B-scan data for the OCT image, the margin width corresponding to a shortest distance between the boundary and a surface of the tissue sample; determining when the margin width is less than a margin threshold; receiving a known optical dataset generated based on measurements of the at least one first optical characteristic for a known set of OCT image data corresponding to a known region in a stored OCT image; and determining a discrimination score based on the second optical dataset and the known optical dataset to indicate a degree of difference between the second region and the known region and comparing the discrimination score to a predefined threshold to identify a high degree of difference between the second region and the known region which indicates that the second and known region comprise different tissue types. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A system for assessing a degree of differentiation for a second region of an OCT image of a tissue sample with respect to a first region, the system comprising:
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a data interface configured to receive OCT image data for the OCT image, the OCT image being a 3D OCT image comprising a plurality of B-scan images; a user interface configured to receive at least one input from a user and to display at least one output to the user; and a processing module coupled to the data interface and the user interface, the processing module being configured; to identify a boundary in the OCT image to identify the second region in the OCT image, the second region being disposed below the boundary; to identify a first set of OCT image data corresponding to the first region and a second set of OCT image data corresponding to the second region; to generate a first optical dataset based on measurements of at least one first optical characteristic for the first set of OCT image data; to generate a second optical dataset based on measurements of the at least one first optical characteristic for the second set of OCT image data; to determine a margin width in B-scan data for the OCT image, the margin width corresponding to a shortest distance between the boundary and a surface of the tissue sample; to determine when the margin width is less than a margin threshold; to receive a known optical dataset generated based on measurements of the at least one first optical characteristic for a known set of OCT image data corresponding to a known region in a stored OCT image; and to determine a discrimination score based on the second optical dataset and the known optical dataset and compare the discrimination score to a predefined threshold to identify a high degree of difference between the second region and the known region which indicates that the second and known region comprise different tissue types. - View Dependent Claims (16, 17, 18, 19)
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20. A non-transitory computer-readable medium storing computer-executable instructions for causing a processor to perform a method of assessing a degree of differentiation for a second region of an OCT image of a tissue sample with respect to a first region, the method comprising:
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receiving OCT image data for the OCT image, the OCT image being a 3D OCT image comprising a plurality of B-scan images; identifying a boundary in the OCT image to identify the second region in the OCT image, the second region being disposed below the boundary; identifying a first set of OCT image data corresponding to the first region and a second set of OCT image data corresponding to the second region; generating a first optical dataset based on measurements of at least one first optical characteristic for the first set of OCT image data; generating a second optical dataset based on measurements of the at least one first optical characteristic for the second set of OCT image data; determining a margin width in B-scan data for the OCT image, the margin width corresponding to a shortest distance between the boundary and a surface of the tissue sample; determining when the margin width is less than a margin threshold; receiving a known optical dataset generated based on measurements of the at least one first optical characteristic for a known set of OCT image data corresponding to a known region in a stored OCT image; and determining a discrimination score based on the second optical dataset and the known optical dataset to indicate a degree of difference between the second region and the known region and comparing the discrimination score to a predefined threshold to identify a high degree of difference between the second region and the known region which indicates that the second and known region comprise different tissue types.
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Specification