Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry using a heartbeat signal for a pregnant mammal

• US 10,362,974 B2
• Filed: 05/07/2018
• Issued: 07/30/2019
• Est. Priority Date: 12/30/2015
• Status: Active Grant

• Current Assignee: Raydiant Oximetry, Inc.
• Original Assignee: Raydiant Oximetry, Inc.
• Inventors: Ray, Neil Padharia
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Liu, Chu Chuan
• Application Number:
  US15/973,141
• Publication Number:
  US 20180256088A1
• Time in Patent Office: 449 Days
• CPC Class Codes: A61B 5/0011 Foetal or obstetric data
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/02411 of foetuses
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1464 specially adapted for foetal tissue
• CPC Class Codes: A61B 5/1482 specially adapted for foetal tissue
• CPC Class Codes: A61B 5/4356 Assessing uterine contractions A61B5/033 takes precedence
• CPC Class Codes: A61B 5/4362 Assessing foetal parameters
• CPC Class Codes: A61B 8/02 Measuring pulse or heart rate
• CPC Class Codes: A61B 8/0866 involving foetal diagnosis; pre-natal or peri-natal diagnosis of the baby
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/488 involving Doppler signals
• CPC Class Codes: A61B 8/56 Details of data transmission or power supply

Abstract

Light reflected from a pregnant woman'"'"'s abdomen and fetus contained therein that has been received by a detector and converted into a reflected electronic signal may be received by a processor. A portion of the reflected electronic signal that is reflected from the fetus may be isolated and the isolated portion of the reflected electronic signal may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. The isolation may be achieved by synchronizing the reflected electronic signal with a fetal heartbeat signal and multiplying the synchronized reflected electronic signal by the synchronized fetal heartbeat signal.

Claims

1. A fetal monitoring system, comprising:

a detector adapted to detect light reflected from an abdomen of a pregnant mammal and a fetus contained therein, the reflected light corresponding to incident light projected into the pregnant mammal'"'"'s abdomen and the fetus by a light source, the detector being further adapted to convert the detected light into a reflected electronic signal and communicate the reflected electronic signal to a processor; and

a processor in communication with the detector, the processor being configured to;

isolate a portion of the reflected electronic signal that corresponds to light reflected from the fetus from the reflected electronic signal, the isolation comprising;

receiving the reflected electronic signal from the detector,

receiving a heartbeat signal for the pregnant mammal,

monitoring the maternal heartbeat signal for a decrease in heartrate corresponding to maternal respiration,

determining a portion of the reflected electronic signal that corresponds with the heartbeat signal for the pregnant mammal and the decrease in heartrate corresponding to maternal respiration,

subtracting the portion of the reflected electronic signal that corresponds with the heartbeat signal and the decrease in heartrate corresponding to maternal respiration for the pregnant mammal from the reflected electronic signal,

analyze the isolated portion of the reflected electronic signal to determine a hemoglobin oxygen saturation level of the fetus; and

facilitate provision of an indication of the hemoglobin oxygen saturation level of the fetus to a display device.

2. The system of claim 1, further comprising:

the light source configured to project light into the abdomen of a pregnant mammal toward a fetus contained therein.

3. The system of claim 2, further comprising:

an adjustment mechanism coupled to the light source and configured to adjust at least one of (i) a frequency of light emitted by the light source, (ii) an incident angle of the light emitted by the light source, and (iii) a focus of a beam of the light.

4. The system of claim 2, further comprising:

an additional light source configured to project light into the abdomen of the pregnant mammal toward the fetus contained therein.

5. The system of claim 2, wherein the light source emits a light of a wavelength within a range at least one of between 700 nm and 740 nm and between 800 and 900 nm.

6. The system of claim 1, further comprising:

an additional detector configured to (i) detect light reflected from the pregnant mammal'"'"'s abdomen, (ii) convert the detected light into an additional reflected electronic signal, and (iii) communicate the additional reflected electronic signal to the processor.

7. The system of claim 1, further comprising:

a temperature probe configured to measure a temperature of the pregnant mammal'"'"'s abdomen and communicate the temperature measurement to the processor, the processor being further configured to provide an indication of the measured temperature to the display device.

8. The system of claim 1, further comprising:

an ultrasonic detector configured to detect ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus and to communicate a signal corresponding to the detected ultrasonic emissions to the processor.

9. The system of claim 1, further comprising:

an ultrasonic detector adapted to detect ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus caused by transient thermoelastic expansion resultant from an interaction of the pregnant mammal'"'"'s abdomen and the fetus'"'"' tissue to light emitted from the light source and communicate a signal corresponding to the detected ultrasonic emissions to the processor.

10. The system of claim 1, further comprising:

a uterine contraction measurement device configured to measure changes in a muscular state of the pregnant mammal'"'"'s uterus and to communicate the measured changes to the processor, the processor being further configured to provide an indication of the measured changes to the display device.

11. The system of claim 1, further comprising:

a transceiver communicatively coupled to at least one of the detector and the processor, the transceiver being configured to receive the reflected electronic signal from the detector and to communicate the received reflected electronic signal to the processor.

12. The system of claim 1, further comprising:

a receiver communicatively coupled to the detector, a source of the pregnant mammal'"'"'s heartbeat signal, and the processor, the receiver being configured to receive the heartbeat signal for the pregnant mammal from the source of the pregnant mammal'"'"'s heartbeat signal and the reflected electronic signal from the detector and to communicate the received heartbeat signal for the pregnant mammal and reflected electronic signal to the processor.

13. The system of claim 1, wherein the processor further receives an indication of the hemoglobin oxygen saturation level of the pregnant mammal, the processor being further configured to analyze the indication of the oxygen saturation level to determine the heartbeat signal for the pregnant mammal.

14. The system of claim 1, further comprising:

synchronizing the reflected electronic signal and the pregnant mammal'"'"'s heartbeat signal prior to determining the portion of the reflected electronic signal that corresponds with the heartbeat signal for the pregnant mammal.

15. A method for determining a fetal hemoglobin oxygen saturation level, the method comprising:

receiving, by a processor, a heartbeat signal for a pregnant mammal from a monitor communicatively coupled to the processor;

receiving, by the processor, a reflected electronic signal from a detector communicatively coupled to the processor, the reflected electronic signal corresponding to light reflected from a pregnant mammal'"'"'s abdomen and a fetus contained therein, the reflected light being a portion of light projected, by a light source, into the pregnant mammal'"'"'s abdomen and fetus contained therein, wherein the reflected light has been converted, by the detector, into the reflected electronic signal;

processing, by the processor, the reflected electronic signal to isolate a portion of the reflected electronic signal that is reflected from the fetus, the processing of the reflected electronic signal comprising;

monitoring the maternal heartbeat signal for a decrease in heartrate corresponding to maternal respiration;

determining a portion of the reflected electronic signal that corresponds with the heartbeat signal for the pregnant mammal and the decrease in heartrate corresponding to maternal respiration;

subtracting the portion of the reflected electronic signal that corresponds with the heartbeat signal and the decrease in heartrate corresponding to maternal respiration for the pregnant mammal from the reflected electronic signal,

analyzing, by the processor, the isolated portion of the reflected electronic signal to determine a fetal hemoglobin oxygen saturation level of the fetus; and

facilitating, by the processor, provision of an indication of the fetal hemoglobin oxygen saturation level to a display device.

16. The method of claim 15, further comprising:

projecting, by the light source, the incident light into the pregnant mammal'"'"'s abdomen.

17. The method of claim 16, further comprising:

adjusting at least one of a frequency of the incident light, an incident angle of the incident light, and a focus of a beam of the incident light.

18. The method of claim 16, further comprising:

determining whether the reflected electronic signal is of sufficient strength; and

adjusting the light source responsively to a determination that the reflected electronic signal is not of sufficient strength.

19. The method of claim 15, further comprising:

determining whether the reflected electronic signal is of sufficient strength; and

adjusting the detector responsively to a determination that the reflected electronic signal is not of sufficient strength.

20. The method of claim 15, wherein the isolation of the portion of the reflected electronic signal further comprises:

receiving, by the processor, an indication of a hemoglobin oxygen saturation level of the pregnant mammal; and

determining, by the processor, how the pregnant mammal'"'"'s hemoglobin interacts with the reflected electronic signal, wherein the subtracting is responsive to the determination of how the pregnant mammal'"'"'s hemoglobin interacts with the reflected electronic signal.

21. The method of claim 15, further comprising:

receiving, by the processor, a signal indicating ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus from an ultrasonic detector in communication with the processor, the ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus being caused by transient thermoelastic expansion resultant from an interaction of the pregnant mammal'"'"'s abdomen and the fetus'"'"' tissue to light emitted from the light source.

22. The method of claim 15, further comprising:

processing, by the processor, the reflected electronic signal to determine a muscular state of the pregnant mammal'"'"'s uterus; and

facilitating, by the processor, provision of an indication of the muscular state of the pregnant mammal'"'"'s uterus to the display device.

23. The method of claim 15, further comprising:

synchronizing, by the processor, the reflected electronic signal and the pregnant mammal'"'"'s heartbeat signal prior to determining the portion of the electronic received signal that corresponds with the heartbeat signal for the pregnant mammal.

24. A computer for determining a fetal hemoglobin oxygen saturation level comprising:

a processor, the processor being configured to;

receive a heartbeat signal for a pregnant mammal from a monitor communicatively coupled to the processor;

receive a reflected electronic signal from a detector communicatively coupled to the processor, the reflected electronic signal corresponding to light reflected from a pregnant mammal'"'"'s abdomen and a fetus contained therein, the reflected light being a portion of light projected, by a light source, into the pregnant mammal'"'"'s abdomen and fetus contained therein, wherein the reflected light has been converted, by the detector, into the reflected electronic signal;

isolate a portion of the reflected electronic signal reflected from the fetus by;

monitoring the maternal heartbeat signal for a decrease in heartrate corresponding to maternal respiration,

determining a portion of the reflected electronic signal that corresponds with the heartbeat signal for the pregnant mammal and the decrease in heartrate corresponding to maternal respiration,

subtracting the portion of the reflected electronic signal that corresponds with the heartbeat signal and the decrease in heartrate corresponding to maternal respiration for the pregnant mammal from the reflected electronic signal,

analyzing, by the processor, the isolated portion of the reflected electronic signal to determine a fetal hemoglobin oxygen saturation level of the fetus; and

facilitating, by the processor, provision of an indication of the fetal hemoglobin oxygen saturation level to a display device.

25. The computer of claim 24, the processor being further configured to isolate of the portion of the reflected electronic signal by:

receiving an indication of a hemoglobin oxygen saturation level of the pregnant mammal; and

determining how the pregnant mammal'"'"'s hemoglobin interacts with the reflected electronic signal, wherein the subtracting is responsive to the determination of how the pregnant mammal'"'"'s hemoglobin interacts with the reflected electronic signal.

26. The computer of claim 24, the processor being further configured to:

receive a signal indicating ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus from an ultrasonic detector in communication with the processor, the ultrasonic emissions of the pregnant mammal'"'"'s abdomen and fetus being caused by transient thermoelastic expansion resultant from an interaction of the pregnant mammal'"'"'s abdomen and the fetus'"'"' tissue to light emitted from the light source.

27. The computer of claim 24, the processor being further configured to:

process the reflected electronic signal to determine a muscular state of the pregnant mammal'"'"'s uterus; and

facilitate provision of an indication of the muscular state of the pregnant mammal'"'"'s uterus to the display device.

28. The computer of claim 24, the processor being further configured to:

synchronize the reflected electronic signal and the pregnant mammal'"'"'s heartbeat signal prior to determining the portion of the reflected electronic signal that corresponds with the heartbeat signal for the pregnant mammal.