Clot retrieval device for removing occlusive clot from a blood vessel

• US 10,363,054 B2
• Filed: 11/25/2015
• Issued: 07/30/2019
• Est. Priority Date: 11/26/2014
• Status: Active Grant

• Current Assignee: Neuravi Limited (Johnson & Johnson)
• Original Assignee: Neuravi Limited (Johnson & Johnson)
• Inventors: Vale, David, Casey, Brendan, Gilvarry, Michael, O'Gorman, Jacqueline, McArdle, Kevin
• Primary Examiner(s): Dornbusch, Dianne
• Application Number:
  US14/952,202
• Publication Number:
  US 20160143653A1
• Time in Patent Office: 1,343 Days
• CPC Class Codes: A61B 17/221 Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions surgical snare instruments A61B17/32056
• CPC Class Codes: A61B 17/320725 with radially expandable cutting or abrading elements A61B17/32075 takes precedence
• CPC Class Codes: A61B 2017/22034 for gripping the obstruction or the tissue part from inside
• CPC Class Codes: A61B 2017/2215 having an open distal end
• CPC Class Codes: A61B 2017/2217 single wire changing shape to a gripping configuration
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section

Abstract

A clot retrieval device for removal of occlusive clot from a blood vessel comprises a clot engaging element 700 having a constrained delivery configuration and an expanded deployed configuration. In the expanded configuration peripheral portions are laterally spaced-apart and the clot engaging section 700 extends between the peripheral portions. The device 700 may have two superimposed wave patterns provided by a large amplitude curve 723 and shorter pitch sinusoidal patterns 721, 722. A wave shape varies the contact pressure between a clot and the device along the length of the device, reducing the compression of the clot by the device at some locations. The device can elongate when placed under tension which aids elongation of the clot during dislodgement.

Claims

1. A clot retrieval device for removing an occlusive clot from a blood vessel comprising:

a planar clot engaging element having a constrained delivery configuration and an expanded deployed configuration, the clot engaging element having a mesh between a plurality of longitudinally extending undulating edges, the clot engaging element comprising;

a first peripheral portion comprising a peak,

a second peripheral portion extended distally from the first peripheral portion, the second peripheral portion comprising a peak, and

a clot engaging section between the peaks of the first and second peripheral portions,

wherein, in the expanded configuration, the peaks of the peripheral portions are laterally spaced-apart and when under tension, configured to pinch the occlusive clot from the blood vessel between the peaks of the peripheral portions in the clot engaging section.

2. A clot retrieval device as claimed in claim 1 wherein the undulating edges have a wave-like form.

3. A clot retrieval device as claimed in claim 2 comprising an activator for modifying the wave shape.

4. A clot retrieval device as claimed in claim 3 wherein the activator comprises at least one push wire connected to the peak of the first peripheral portion and at least one pull wire connected to the peak of the second peripheral portion,

wherein a wave profile of the body section defined by the first and second peripheral portion is modifiable thereby by actuating the at least one push and pull wires thereby changing a pitch distance between the peaks.

5. A clot retrieval device as claimed in claim 2 wherein the wave pattern has an amplitude of from 2.0 mm to 6.0 mm.

6. A clot retrieval device as claimed in claim 2 wherein the wave pattern has a pitch of from 3.0 mm to 8.0 mm.

7. A clot retrieval device as claimed in claim 2 wherein the clot engaging section comprises a plurality of cells defined by struts and crowns connected to corresponding struts and/or crowns of the first and second peripheral portions, and wherein at least some of the struts and/or crowns of the clot engaging section are aligned with the wave-like form to enhance embedding of clot.

8. A clot retrieval device as claimed in claim 1 wherein the undulating edges have a sinusoidal wave form.

9. A clot retrieval device as claimed in claim 1 wherein the device has at least two wave patterns.

10. A clot retrieval device as claimed in claim 9 wherein the wave patterns are superimposed on one another.

11. A clot retrieval device as claimed in claim 9 wherein a first pattern has a wavelength and an amplitude and the second pattern has a wavelength and an amplitude which are larger than those of the first pattern.

12. A clot retrieval device as claimed in claim 1 wherein the clot engagement element comprises one or more clot gripping features defined by a strut framework of the first and second peripheral portions.

13. A clot retrieval device as claimed in claim 1 wherein in the constrained and expanded configurations the clot engaging section is substantially curvilinear.

14. A clot retrieval device as claimed in claim 1 wherein the clot engaging element the peak of the first and second peripheral portions comprise a surface oriented in generally opposite directions and one or both of the surfaces of the first and second peripheral portions is configured to pinch the occlusive clot in the expanded deployed configuration.

15. A clot retrieval device as claimed in claim 1 wherein the device comprises a proximal section, a distal section and a clot engaging section between the proximal section and the distal section wherein the proximal section is slidably movable relative to the clot engaging section.

16. A clot retrieval device as claimed in claim 15 wherein the proximal section comprises a collar and proximal struts extending from the collar and the clot engaging section comprises a proximal shaft and the collar is slidably movable relative to the proximal shaft.

17. A clot retrieval device as claimed in claim 16 wherein at least some of the struts of the proximal section extend in a distal direction for at least partial capture of clot between the clot engaging section and the proximal struts on proximal movement of the collar relative to the proximal shaft.

18. A clot retrieval device as claimed in claim 1 wherein the clot engaging section of the device has a transverse cross section between the peaks of the first and second peripheral portions having both flat and curved sections.

19. A clot retrieval device as claimed in claim 1 wherein, in the expanded configuration, at least a portion of the clot engaging section of the device is a generally spiral or helical configuration relative to a longitudinal axis.

20. A clot retrieval device as claimed in claim 19 wherein the clot engaging section further comprises a distal tubular section.

21. A clot retrieval device as claimed in claim 20 having a clot fragment portion at the distal end of the tubular section.

22. A clot retrieval device as claimed in claim 1 wherein the clot engaging section comprises a plurality of segments, adjacent segments being aligned at approximately 90°

to each other.

23. A clot retrieval device as claimed in claim 22 wherein at least some of the segments are of flat shape in transverse cross section.

24. A clot retrieval device as claimed in claim 1 comprising a distal clot fragment protection section.