Ocular implants for delivery into the eye

• US 10,363,168 B2
• Filed: 09/02/2015
• Issued: 07/30/2019
• Est. Priority Date: 06/14/2011
• Status: Active Grant

• Current Assignee: Alcon Incorporated
• Original Assignee: Ivantis Inc. (Alcon Incorporated)
• Inventors: Schieber, Andrew T., Galt, Kenneth M.
• Primary Examiner(s): Zimbouski, Ariana
• Application Number:
  US14/843,563
• Publication Number:
  US 20150366710A1
• Time in Patent Office: 1,427 Days
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61F 9/00781 Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment drainage implants in general A61M27/002
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

An ocular implant adapted to reside at least partially in a portion of Schlemm'"'"'s canal of an eye. The implant includes a spine extending along a longitudinal axis of the implant, a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that each support forms a portion of a helix, the spine and supports defining a volume having a maximum width perpendicular to the longitudinal axis between 0.005 inches and 0.04 inches, the ocular implant being configured to bend preferentially in a preferential bending plane.

Claims

1. A method of deploying at least a distal portion of an ocular implant into Schlemm'"'"'s canal of an eye, the ocular implant comprising a plurality of curved supports, each support comprising a first end extending from a first location on a first side of the ocular implant and a second end extending from a second location on a second side of the ocular implant, the second location being proximal to the first location, so that each support forms a portion of a helix and the plurality of curved supports collectively forms a helix, the eye having a cornea defining an anterior chamber and an iris defining a pupil, the method comprising:

advancing a distal portion of a cannula through the cornea so that a curved portion of the cannula is at least partially disposed in the anterior chamber of the eye;

advancing a distal tip of the cannula through trabecular meshwork of the eye so that a distal opening of the cannula is placed in fluid communication with Schlemm'"'"'s canal;

advancing the ocular implant through the curved portion of the cannula;

rotating the ocular implant as at least a distal portion of the ocular implant is advanced through the distal opening and into Schlemm'"'"'s canal; and

using the curved supports to advance the ocular implant into Schlemm'"'"'s canal as the ocular implant is rotated.

2. The method of claim 1 further comprising producing alternating stretching and relaxing of Schlemm'"'"'s canal during the rotating step.

3. The method of claim 1 wherein the ocular implant further comprises a spine portion extending longitudinally along the ocular implant, the plurality of supports extending from the spine portion, the method further comprising aligning the spine portion in a location offset from a major wall of Schlemm'"'"'s canal.

4. The method of claim 1 further comprising positioning the ocular implant within Schlemm'"'"'s canal while minimizing the likelihood that the ocular implant will obstruct collector channels of the eye.

5. The method of claim 1 wherein the rotating step further comprises increasing permeability of the trabecular meshwork.

6. A method of deploying at least a distal portion of an ocular implant into Schlemm'"'"'s canal of an eye, the ocular implant comprising a plurality of curved supports, each support comprising a first end extending from a first location on a first side of the ocular implant and a second end extending from a second location on a second side of the ocular implant, the second location being proximal to the first location, so that the plurality of curved supports collectively forms a helix, the method comprising:

advancing a distal portion of a cannula through a cornea of the eye so that a curved portion of the cannula is at least partially disposed in an anterior chamber of the eye;

advancing a distal tip of the cannula through trabecular meshwork of the eye so that a distal opening of the cannula is placed in fluid communication with Schlemm'"'"'s canal;

advancing the ocular implant through the curved portion of the cannula;

using the curved supports to assist advance of the ocular implant into Schlemm'"'"'s canal; and

producing alternating stretching and relaxing of Schlemm'"'"'s canal during the advancing step.

7. The method of claim 6 further comprising rotating the ocular implant as at least a distal portion of the ocular implant is advanced through the distal opening and into Schlemm'"'"'s canal.

8. The method of claim 6 wherein the ocular implant further comprises a spine portion extending longitudinally along the ocular implant, the plurality of curved supports are spaced apart and extend from the spine portion, the method further comprising aligning the spine portion in a location offset from a major wall of Schlemm'"'"'s canal.

9. The method of claim 8 wherein each support comprises a first end extending from a first location on a first side of the spine portion and a second end extending from a second location on a second side of the spine portion, the second location being proximal to the first location, so that each support forms a portion of a helix.

10. The method of claim 6 further comprising positioning the ocular implant within Schlemm'"'"'s canal while minimizing the likelihood that the ocular implant will obstruct collector channels of the eye.

11. The method of claim 6 wherein the step of producing alternating stretching and relaxing of Schlemm'"'"'s canal further comprises increasing the permeability of the trabecular meshwork.

12. A method of deploying at least a distal portion of an ocular implant into Schlemm'"'"'s canal of an eye, the eye having a cornea defining an anterior chamber and an iris defining a pupil, the ocular implant comprising a spine portion extending longitudinally along the ocular implant and a plurality of curved supports extending from the spine, each support comprising a first end extending from a first location on a first side of the spine and a second end extending from a second location on a second side of the spine, the second location being proximal to the first location, so that the plurality of curved supports collectively forms a helix, the method comprising:

advancing a distal portion of a cannula through the cornea so that a curved portion of the cannula is at least partially disposed in the anterior chamber of the eye;

advancing a distal tip of the cannula through trabecular meshwork of the eye so that a distal opening of the cannula is placed in fluid communication with Schlemm'"'"'s canal;

advancing the ocular implant through the curved portion of the cannula, the ocular implant comprising a plurality of spaced apart supports; and

using the supports to assist advance of the ocular implant into Schlemm'"'"'s canal.

13. The method of claim 12 wherein the step of using the supports to assist advance of the ocular implant into Schlemm'"'"'s canal comprises rotating the ocular implant.

14. The method of claim 12 further comprising positioning the ocular implant within Schlemm'"'"'s canal while minimizing the likelihood that the ocular implant will obstruct collector channels of the eye.

15. The method of claim 12 further comprising producing alternating stretching and relaxing of Schlemm'"'"'s canal during the advancing step.