Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
First Claim
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1. A method of treating a skin, mucosal, or body cavity disorder comprising administering to skin, mucosal, or body cavity a composition comprising:
- a) about 1% to about 5% of a minocycline;
b) one or more short chain alcohols comprising ethanol;
c) about 2% to about 50% by weight of the composition of one or more protic polar solvents comprising propylene glycol;
d) one or more polymeric agents comprising a cellulose ether;
e) one or more modulating agents comprising an antioxidizing agent;
f) a metal; and
g) an essential oil;
wherein the composition is essentially free of fatty alcohol;
wherein the composition is surfactant free; and
wherein the composition is waterless.
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Abstract
The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
1022 Citations
26 Claims
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1. A method of treating a skin, mucosal, or body cavity disorder comprising administering to skin, mucosal, or body cavity a composition comprising:
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a) about 1% to about 5% of a minocycline; b) one or more short chain alcohols comprising ethanol; c) about 2% to about 50% by weight of the composition of one or more protic polar solvents comprising propylene glycol; d) one or more polymeric agents comprising a cellulose ether;
e) one or more modulating agents comprising an antioxidizing agent;f) a metal; and g) an essential oil; wherein the composition is essentially free of fatty alcohol; wherein the composition is surfactant free; and wherein the composition is waterless. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of treating a skin, mucosal, or body cavity disorder comprising administering to skin, mucosal, or body cavity a composition comprising:
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a) about 1% to about 5% of a minocycline; b) one or more short chain alcohols comprising ethanol present in an amount of at least 55% by weight of the composition; c) about 2% to about 50% by weight of the composition of one or more protic polar solvents comprising propylene glycol; d) one or more polymeric agents comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present in an amount ranging from about 0.5% to about 1% by weight of the composition; e) one or more modulating agents comprising an antioxidizing agent present in an amount ranging from about 0.1% to about 10% by weight of the composition; f) a metal; and g) an essential oil; wherein the composition is free or essentially free of fatty alcohol; wherein the composition is surfactant free; and wherein the composition is waterless. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26)
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Specification