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Method of manufacturing an osmotic delivery device

  • US 10,363,287 B2
  • Filed: 06/02/2017
  • Issued: 07/30/2019
  • Est. Priority Date: 02/03/2005
  • Status: Active Grant
First Claim
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1. A method of manufacturing an osmotic delivery device comprising loading a suspension formulation into a reservoir of the osmotic delivery device,the suspension formulation comprising:

  • a particle formulation comprisingan insulinotropic peptide, an antioxidant, and a buffer, wherein the insulinotropic peptide is at least one of exenatide, a derivative of exenatide, and an analogue of exenatide; and

    a non-aqueous, single-phase suspension vehicle that comprises about 20 wt % to about 60 wt % solvent and about 80 wt % to about 40 wt % pyrrolidone polymer, the suspension vehicle having a viscosity from 5,000 poise to 50,000 poise at 33°

    C.;

    wherein;

    the solvent is at least one of lauryl lactate, lauryl alcohol, and benzyl benzoate;

    30 to 90% by weight of the particle formulation is the insulinotropic peptide;

    the particle formulation has a wt % ratio of insulinotropic peptide to antioxidant of 2.5/1 to 10/1; and

    the particle formulation is dispersed in the suspension vehicle.

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