Vaccine composition
First Claim
1. A method for treating a patient having a cancer, said method comprising:
- a) a first virus, said first virus comprising a nucleic acid that is capable of expressing a MAGEA3 protein, said MAGEA3 protein comprising an amino acid sequence that is at least 70% identical to SEQ ID NO;
1, and includes at least one MAGEA3 tumor-associated epitope selected from the group consisting of;
FLWGPRALV (SEQ ID NO;
27), KVAELVHFL (SEQ ID NO;
28), EGDCAPEEK (SEQ ID NO;
35), KKLLTQHFVQENYLEY (SEQ ID NO;
36), and RKVAELVHFLLLKYR (SEQ ID NO;
37), wherein said MAGEA3 protein is capable of inducing an immune response in a patient in a heterologous prime-boost format, andb) a second virus, said second virus being a Maraba MG1 virus comprising a nucleic acid that is capable of expressing a MAGEA3 protein, said MAGEA3 protein comprising an amino acid sequence that is at least 70% identical to SEQ ID NO;
1, and includes at least one MAGEA3 tumor-associated epitope selected from the group consisting of;
FLWGPRALV (SEQ ID NO;
27), KVAELVHFL (SEQ ID NO;
28), EGDCAPEEK (SEQ ID NO;
35), KKLLTQHFVQENYLEY (SEQ ID NO;
36), and RKVAELVHFLLLKYR (SEQ ID NO;
37), wherein said Maraba MG1 virus is formulated for use in providing a therapeutic oncolytic effect in said patient;
wherein;
said first virus is immunologically distinct from said second virus;
said first virus is a priming virus and administered before said second virus; and
whereinsaid second virus is a boost virus and is administered at least twice after administration of said priming virus.
7 Assignments
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Accused Products
Abstract
There is described a kit for use in inducing an immune response in a mammal, the kit includes: a first virus that expresses MAGEA3, Human Papilloma Virus E6/E7 fusion protein, human Six-Transmembrane Epithelial Antigen of the Prostate protein, or Cancer Testis Antigen 1, or a variant thereof as an antigenic protein and that is formulated to generate an immunity to the protein or variant thereof in the mammal. The kit also includes a Maraba MG1 virus encoding the same antigen, or a variant of the same antigen. The Maraba MG1 virus is formulated to induce the immune response in the mammal. The first virus is immunologically distinct from the Maraba MG1 virus.
123 Citations
21 Claims
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1. A method for treating a patient having a cancer, said method comprising:
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a) a first virus, said first virus comprising a nucleic acid that is capable of expressing a MAGEA3 protein, said MAGEA3 protein comprising an amino acid sequence that is at least 70% identical to SEQ ID NO;
1, and includes at least one MAGEA3 tumor-associated epitope selected from the group consisting of;
FLWGPRALV (SEQ ID NO;
27), KVAELVHFL (SEQ ID NO;
28), EGDCAPEEK (SEQ ID NO;
35), KKLLTQHFVQENYLEY (SEQ ID NO;
36), and RKVAELVHFLLLKYR (SEQ ID NO;
37), wherein said MAGEA3 protein is capable of inducing an immune response in a patient in a heterologous prime-boost format, andb) a second virus, said second virus being a Maraba MG1 virus comprising a nucleic acid that is capable of expressing a MAGEA3 protein, said MAGEA3 protein comprising an amino acid sequence that is at least 70% identical to SEQ ID NO;
1, and includes at least one MAGEA3 tumor-associated epitope selected from the group consisting of;
FLWGPRALV (SEQ ID NO;
27), KVAELVHFL (SEQ ID NO;
28), EGDCAPEEK (SEQ ID NO;
35), KKLLTQHFVQENYLEY (SEQ ID NO;
36), and RKVAELVHFLLLKYR (SEQ ID NO;
37), wherein said Maraba MG1 virus is formulated for use in providing a therapeutic oncolytic effect in said patient;
wherein;said first virus is immunologically distinct from said second virus; said first virus is a priming virus and administered before said second virus; and
whereinsaid second virus is a boost virus and is administered at least twice after administration of said priming virus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification