Method for preparing a chitosan-based porous layer
First Claim
1. A method for preparing a chitosan-based porous layer which has been compressed, neutralized and washed, comprising the following steps:
- a) preparing a chitosan solution free of any other polymer, including a chitosan concentration ranging from 1.0% to 5% by weight, relative to a total weight of the solution and having a pH from 3 to 5,b) pouring the chitosan solution into a mold in order to form a layer,c) lyophilizing the layer obtained in b) to obtain a porous layer,d) compressing the porous layer obtained in c) to obtain a compressed porous layer including a density of greater than or equal to 0.65 g/cm3,e) neutralizing the compressed porous layer obtained in d) by using a NH4OH solution comprising a NH4OH concentration ranging from 0.6 to 2 mold to obtain a neutralized compressed porous layer, and,f) subjecting the neutralized compressed porous layer obtained in e) to one or more washing steps.
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Abstract
Method for preparing a chitosan-based porous layer The present invention relates to a method or preparing a chitosan-based, neutralized compressed porous layer, comprising the following steps: —a) a chitosan solution is prepared, —b) said solution is poured into a mold in order to form a layer, —c) the layer obtained in b) is lyophilized so as to obtain a porous layer, —d) said porous layer obtained in c) is compressed, —e) the compressed porous layer obtained in d) is neutralized by means of an NH4OH solution. It also relates to an implant comprising a layer obtained according to such a method.
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Citations
20 Claims
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1. A method for preparing a chitosan-based porous layer which has been compressed, neutralized and washed, comprising the following steps:
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a) preparing a chitosan solution free of any other polymer, including a chitosan concentration ranging from 1.0% to 5% by weight, relative to a total weight of the solution and having a pH from 3 to 5, b) pouring the chitosan solution into a mold in order to form a layer, c) lyophilizing the layer obtained in b) to obtain a porous layer, d) compressing the porous layer obtained in c) to obtain a compressed porous layer including a density of greater than or equal to 0.65 g/cm3, e) neutralizing the compressed porous layer obtained in d) by using a NH4OH solution comprising a NH4OH concentration ranging from 0.6 to 2 mold to obtain a neutralized compressed porous layer, and, f) subjecting the neutralized compressed porous layer obtained in e) to one or more washing steps. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of forming an implant for reinforcing a staple zone including a chitosan based porous layer comprising the following steps:
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a) preparing a chitosan solution free of any other polymer and including a chitosan concentration ranging from 1.0% to 5% by weight, relative to the total weight of the solution, b) adjusting the pH of the chitosan solution to a pH ranging from 3 to 5, c) pouring the solution into a mold in order to form a layer, d) lyophilizing the layer obtained in c) to obtain a porous layer, e) compressing the porous layer obtained in d) to obtain a compressed porous layer including a density of greater than equal to 0.65 g/cm3, f) neutralizing the compressed porous layer obtained in e) by using a NH4OH solution comprising a NH4OH concentration ranging from 0.6 to 2 mol/l to obtain a neutralized compressed porous layer, and, g) subjecting the neutralized compressed porous layer obtained in f) to one or more washing steps. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification