Methods and intermediates for synthesizing SK1-I

• US 10,364,211 B1
• Filed: 10/24/2018
• Issued: 07/30/2019
• Est. Priority Date: 10/25/2017
• Status: Active Grant

• Current Assignee: Enzo Biochem Incorporated
• Original Assignee: Enzo Biochem Incorporated
• Inventors: Li, Zaiguo, Raju, Natarajan, Pande, Praveen
• Primary Examiner(s): Brooks, Clinton A
• Application Number:
  US16/169,056
• Publication Number:
  US 20190256453A1
• Time in Patent Office: 279 Days
• Field of Search: None
• CPC Class Codes: C07B 2200/07 Optical isomers
• CPC Class Codes: C07C 213/08 by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
• CPC Class Codes: C07C 215/28 and containing six-membered aromatic rings
• CPC Class Codes: C07C 269/04 from amines with formation of carbamate groups
• CPC Class Codes: C07C 269/06 by reactions not involving the formation of carbamate groups
• CPC Class Codes: C07C 271/16 to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
• CPC Class Codes: C07C 271/22 to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• CPC Class Codes: C07D 263/06 with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms

Abstract

The invention provides methods for synthesizing the compound (2R,3S,4E)-N-methyl-5-(4′-pentylphenyl)-2-aminopent-4-ene-1,3-diol, also known as SK1-I, and intermediate compounds used in its synthesis.

Claims

1. A method for synthesizing the compound