Fast diagnosis and personalized treatments for acne

• US 10,364,473 B2
• Filed: 09/06/2016
• Issued: 07/30/2019
• Est. Priority Date: 03/17/2012
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Li, Huiying, Tomida, Shuta, Modlin, Robert L., Miller, Jeffery F., Fitz-Gibbon, Sorel T.
• Primary Examiner(s): Minnifield, Nita M.
• Application Number:
  US15/257,423
• Publication Number:
  US 20170058328A1
• Time in Patent Office: 1,057 Days
• Field of Search: None
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 35/76 Viruses; Subviral particles; Bacteriophages
• CPC Class Codes: A61K 39/0208 Specific bacteria not otherwise provided for
• CPC Class Codes: A61K 39/05 Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium Mycobacterium A61K39/04
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: C12N 2795/00032 Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
• CPC Class Codes: C12N 7/00 Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K39/00
• CPC Class Codes: C12Q 1/6883 for diseases caused by alterations of genetic material
• CPC Class Codes: C12Q 1/689 for bacteria
• CPC Class Codes: C12Q 1/701 Specific hybridization probes
• CPC Class Codes: C12Q 2600/112 Disease subtyping, staging or classification
• CPC Class Codes: C12Q 2600/156 Polymorphic or mutational markers
• CPC Class Codes: C12Q 2600/16 Primer sets for multiplex assays

Abstract

Methods of diagnosing and treating patients afflicted with acne, including diagnosing one as having acne if the individual possesses RT4, RT5, RT7, RT8, RT9, or RT10. Methods for treating acne include administering an effective amount of a drug specifically targeting RT4, RT5, RT7, RT8, RT9, or RT10, such as small molecules, antisense molecules, siRNAs, biologics, antibodies, phages, vaccines, or combination thereof.

Claims

1. A method for treating acne in a subject in need thereof, comprising:

administering an effective amount of a composition comprising an RT6 strain of P. acnes to the subject.

2. The method of claim 1, wherein the strain has at least 99% homology to SEQ ID NO:

6.

3. The method of claim 2, wherein the strain has at least 100% homology to SEQ ID NO:

6.

4. The method of claim 1, wherein the strain has at least 95% homology to SEQ ID NO:

51, SEQ ID NO;

52, SEQ ID NO;

53, or SEQ ID NO;

54.

5. The method of claim 4, wherein the strain has at least 99% homology to SEQ ID NO:

51, SEQ ID NO;

52, SEQ ID NO;

53, or SEQ ID NO;

54.

6. The method of claim 5, wherein the strain has at least 100% homology to SEQ ID NO:

51, SEQ ID NO;

52, SEQ ID NO;

53, or SEQ ID NO;

54.

7. The method of claim 1, wherein the composition is formulated for topical application.

8. The method of claim 7, wherein the composition is formulated as a cream.