Light harvesting multichromophore compositions and methods of using the same
First Claim
1. An aqueous composition comprising an aggregate of light harvesting multichromophore conjugated polymers in an aqueous solution that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith in the aqueous solution, wherein the light harvesting multichromophore conjugated polymers comprise water soluble groups and are linked to a sensor biomolecule that specifically binds a target.
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Abstract
Light harvesting luminescent multichromophores that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith are provided. Also provided are compositions for labelling a target. The labelling composition may include a donor light harvesting multichromophore and an acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore. Also provided is an aqueous composition for labelling a target, including: a donor light harvesting multichromophore; an acceptor signaling chromophore in energy-receiving proximity therewith; and a sensor biomolecule. Methods for using the subject compositions are also provided.
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29 Claims
- 1. An aqueous composition comprising an aggregate of light harvesting multichromophore conjugated polymers in an aqueous solution that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith in the aqueous solution, wherein the light harvesting multichromophore conjugated polymers comprise water soluble groups and are linked to a sensor biomolecule that specifically binds a target.
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10. An aqueous labelling composition comprising:
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a donor light harvesting multichromophore system comprising an aggregate of conjugated polymers in an aqueous solution that upon excitation are capable of transferring energy to an acceptor signaling chromophore, wherein the conjugated polymers comprise water soluble groups; and the acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore in the aqueous solution; wherein the donor light harvesting multichromophore system comprises conjugated polymers of aromatic repeat units and the ratio of the number of repeat units to the acceptor signaling chromophore is 100;
1 or more. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. An aqueous composition for labelling a target, the composition comprising:
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a donor light harvesting multichromophore system comprising an aggregate of conjugated polymers in an aqueous solution that upon excitation are capable of transferring energy to an acceptor signaling chromophore, wherein the conjugated polymers comprise water soluble groups; the acceptor signaling chromophore in energy-receiving proximity to the donor light harvesting multichromophore in the aqueous solution; and a sensor biomolecule. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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Specification