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Neural measurement

  • US 10,368,762 B2
  • Filed: 05/05/2015
  • Issued: 08/06/2019
  • Est. Priority Date: 05/05/2014
  • Status: Active Grant
First Claim
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1. A method for measuring a neural response to a stimulus, the method comprising:

  • applying an electrical stimulus from stimulus electrodes to neural tissue;

    imposing a delay during which the stimulus electrodes are open circuited; and

    during the delay, measuring a neural response signal present at sense electrodes with a measurement amplifier, while ensuring that an impedance between the sense electrodes is sufficiently large that a voltage arising on the sense electrode tissue interface in response to the stimulus is constrained to a level which permits assessment of the neural response voltage seen at the sense electrode,wherein an input impedance to the measurement amplifier (ZIN) is limited by;


    ZIN>



    Z
    C(Vs1

    V
    s2)/VE whereA is a scalar provided to give sufficient margin of VE over (Vs1

    Vs2),ZC is the constant phase element impedance of the or each sense electrode,Vs1

    Vs2 is the differential voltage arising on the sense electrode tissue interface in response to the stimulus, andVE is the neural response voltage seen at the sense electrode.

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