Estimation of acoustic level in-situ with non-fundamental analysis

• US 10,368,842 B2
• Filed: 04/03/2015
• Issued: 08/06/2019
• Est. Priority Date: 04/07/2014
• Status: Active Grant

• Current Assignee: Bracco Suisse SA
• Original Assignee: Bracco Suisse SA
• Inventors: Casqueiro, Gilles, Gaud, Emmanuel, Arditi, Marcel, Frinking, Peter
• Primary Examiner(s): Carey, Michael J
• Application Number:
  US15/302,467
• Publication Number:
  US 20170027545A1
• Time in Patent Office: 1,586 Days
• Field of Search: 600431
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/5269 involving detection or reduction of artifacts for image enhancement algorithms G06T5/00
• CPC Class Codes: A61B 8/58 Testing, adjusting or calibrating the diagnostic device
• CPC Class Codes: A61N 2007/0039 using microbubbles
• CPC Class Codes: A61N 2007/0052 using the same transducer for therapy and imaging
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A method is provided for use with an ultrasound scanner, wherein an estimate value (particularly, a power level of the ultrasound scanner that is required to apply a desired acoustic pressure level to the body-part, the acoustic pressure level that is actually applied to the body-part when a specific power level is set, an acoustic attenuation that occurs within a patient between a transducer of the ultrasound scanner and the body-part and/or the acoustic attenuation that occurs within the patient between different body-parts) is determined according to a comparison between measurement data (based on a measurement response comprising a non-fundamental component of a measurement echo signal received in response to a measurement excitation signal) and corresponding reference data. Corresponding computer program product, system, therapeutic method, and diagnostic method are also provided.

Claims

1. A method for use with an ultrasound scanner, the method comprising:

applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method,

recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and

determining an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response, said determining an estimate value being implemented by any one or more of the following steps;

a1) estimating a target power level required to apply a selected target acoustic pressure level to the body-part further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

a2) estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

b) estimating a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and

c) estimating a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part.

2. The method according to claim 1, comprising:

applying a calibration excitation signal, comprising ultrasound waves generated by varying the power level of the ultrasound scanner in a calibration range, with the transducer to the calibration structure, and

recording the level of said non-fundamental component of the calibration echo signal received in response to the calibration excitation signal.

3. The method according to claim 2, comprising:

measuring the acoustic pressure level applied to the contrast agent in the calibration structure by the calibration excitation signal.

4. The method according to claim 2, wherein the contrast agent in the calibration structure has a concentration lower than a threshold value providing a substantially null attenuation of the calibration excitation signal and of the calibration echo signal.

5. The method according to claim 1, comprising:

applying a further measurement excitation signal with the transducer to the further body-part, and

recording the level of said non-fundamental component of the further measurement echo signal received in response to the further measurement excitation signal.

6. The method according to claim 1, wherein said determining an estimate value comprises:

fitting the measurement response by a measurement function, and

determining the estimate value according to a comparison between the measurement function and a reference function fitting the reference response.

7. The method according to claim 6, wherein the measurement function and the reference function are instances of a model function with a generic S-shape, the model function comprising a final constant segment with a substantially constant final value, a further constant segment with a substantially constant further value, and an increasing segment between the further constant segment and the final constant segment wherein the model function increases substantially monotonically from the further constant value to the final constant value.

8. The method according to claim 7, wherein the model function further comprises an initial constant segment with a substantially initial value, and a further increasing segment between the initial constant segment and the further constant segment wherein the model function increases substantially monotonically from the initial constant value to the further constant value.

9. The method according to claim 7, wherein said determining an estimate value comprises:

determining a measurement point being characteristic of the increasing segment of the measurement function, and

determining the estimate value according to a comparison between the measurement point and a reference point being characteristic of the increasing segment of the reference function.

10. The method according to claim 9, wherein said determining an estimate value comprises:

determining the measurement point in correspondence to an intersection between the further constant segment and the increasing segment of the measurement function, and

determining the estimate value according to a comparison between the measurement point and the reference point in correspondence to an intersection between the further constant segment and the increasing segment of the reference function.

11. The method according to claim 10, wherein said determining an estimate value comprises:

determining the measurement point in correspondence to a descending vertical asymptote of the increasing segment of the measurement function, and

determining the estimate value according to a comparison between the measurement point and the reference point in correspondence to a descending vertical asymptote of the increasing segment of the reference function.

12. The method according to claim 9, wherein the reference point is a calibration point being characteristic of the increasing segment of a calibration function fitting the calibration response, said determining an estimate value comprising:

estimating the target power level and/or the further target acoustic pressure level by applying the pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner to a measurement power level identified by the measurement point and a calibration acoustic pressure level identified by the calibration point.

13. The method according to claim 9, wherein the reference point is a further calibration point being characteristic of the increasing segment of a further calibration function fitting the further calibration response, said estimating a total acoustic attenuation comprising:

estimating the total acoustic attenuation according to a comparison between a measurement power level identified by the measurement point and a calibration power level identified by the further calibration point.

14. The method according to claim 9, wherein the reference point is a further measurement point being characteristic of the increasing segment of a further measurement function fitting the further measurement response, said estimating a partial acoustic attenuation comprising:

estimating the partial acoustic attenuation according to a comparison between a measurement power level identified by the measurement point and a further measurement power level identified by the further measurement point.

15. The method according to claim 1, wherein the body-part and the further body-part are at different depths in the patient from a skin thereof.

16. The method according to claim 1, wherein said non-fundamental component is a sub-harmonic component of the echo signal.

17. The method according to claim 16, wherein said sub-harmonic component is equal to ½

a fundamental frequency of the echo signal.

18. The method according to claim 1, wherein said applying a measurement excitation signal comprises:

applying a first measurement excitation signal and a second measurement excitation signal opposite the first measurement excitation signal, and wherein said recording a measurement response comprises;

recording a first measurement response in response to the first measurement excitation signal and a second measurement response in response to the second measurement excitation signal and obtaining the measurement response according to a combination of the first measurement response and the second measurement response.

19. The method according to claim 1, comprising:

controlling the ultrasound scanner according to the target power level.

20. A computer program product comprising a non-transitory computer readable storage medium embodying a computer program, the computer program being loadable into a working memory of a computing system thereby configuring the computing system to perform a method for use with an ultrasound scanner, the method comprising:

applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient before performing the method,

recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and

determining an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response, said determining an estimate value comprising any one or more of;

a1) estimating a target power level required to apply a selected target acoustic pressure level to the body-part further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

a2) estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

b) estimating a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and

c) estimating a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part.

21. A system for use with an ultrasound scanner, the system comprising:

a circuit for applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of the ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to a body-part of a patient comprising a contrast agent being pre-administered to the patient,

a circuit for recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, and

a circuit for determining an estimate value according to a comparison between measurement data based on the measurement response and reference data based on a reference response, said circuit for determining an estimate value comprising one or more of the following circuits;

a1) a circuit for estimating a target power level required to apply a selected target acoustic pressure level to the body-part further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

a2) a circuit for estimating a further target acoustic pressure level applied to the body-part when a selected further target power level is set further according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner when the reference response is a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent,

b) a circuit for estimating a total acoustic attenuation occurring within the patient between the transducer and the body-part when the reference response is a further calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in the in-vitro calibration structure, and

c) a circuit for estimating a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient when the reference response is a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part.

24. An ultrasound scanner comprising the system of claim 21.

22. A therapeutic method comprising:

administering a contrast agent to a patient to cause the contrast agent to perfuse a body-part of the patient,

applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of an ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to the body-part,

recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, a target power level required to apply a selected target acoustic pressure level to the body-part being estimated according to a comparison between measurement data based on the measurement response and reference data based on a calibration response expressing the level of said non-fundamental component of a calibration echo signal as a function of the acoustic pressure level in an in-vitro calibration structure comprising the contrast agent and according to a pre-defined relation between the power level and the acoustic pressure level of the ultrasound scanner, and

applying further ultrasound waves, generated by setting the power level of the ultrasound scanner according to said target power level, to the body-part.

23. A diagnostic method comprising:

administering a contrast agent to a patient to cause the contrast agent to perfuse a body-part of the patient,

applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of an ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to the body-part,

recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, a total acoustic attenuation occurring within the patient between the transducer and the body-part being estimated according to a comparison between measurement data based on the measurement response and reference data based on a calibration response expressing the level of said non-fundamental component of the calibration echo signal as a function of the power level in an in-vitro calibration structure comprising the contrast agent, and

evaluating a health condition of the body-part according to the total acoustic attenuation.

25. A diagnostic method comprising:

administering a contrast agent to a patient to cause the contrast agent to perfuse a body-part of the patient,

applying a measurement excitation signal, comprising ultrasound waves generated by varying a power level of an ultrasound scanner in a measurement range, with a transducer of the ultrasound scanner to the body-part,

recording a measurement response comprising a level of a non-fundamental component of a measurement echo signal received in response to the measurement excitation signal, a partial acoustic attenuation occurring within the patient between the body-part and a further body-part of the patient being estimated according to a comparison between measurement data based on the measurement response and reference data based on a further measurement response expressing the level of said non-fundamental component of a further measurement echo signal as a function of the power level in the further body-part, and

evaluating a health condition of the body-part according to the partial acoustic attenuation.