Embolic compositions

• US 10,368,874 B2
• Filed: 08/25/2017
• Issued: 08/06/2019
• Est. Priority Date: 08/26/2016
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Baldwin, Aaron, Mehta, Ami, Lam, Jonathan
• Primary Examiner(s): Rosenthal, Andrew S
• Application Number:
  US15/687,263
• Publication Number:
  US 20180055516A1
• Time in Patent Office: 711 Days
• CPC Class Codes: A61B 17/12181 formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/00938 hydrophobic
• CPC Class Codes: A61B 2017/00942 hydrophilic
• CPC Class Codes: A61B 2090/3933 Liquid markers
• CPC Class Codes: A61B 2090/3966 Radiopaque markers visible in an X-ray image
• CPC Class Codes: A61K 31/785 Polymers containing nitrogen
• CPC Class Codes: A61K 49/0438 Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
• CPC Class Codes: A61K 49/0442 Polymeric X-ray contrast-enhancing agent comprising a halogenated group
• CPC Class Codes: C08F 20/26 Esters containing oxygen in addition to the carboxy oxygen
• CPC Class Codes: C08L 33/14 of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen

Abstract

Described herein are compositions comprising, a polymer; a non-physiological solution; and a visualization agent; wherein the polymer is soluble in the non-physiological solution and insoluble at physiological conditions. Methods of preparing the compositions are disclosed as well as methods of using these compositions to treat vascular conditions.

Claims

1. A composition comprising:

1) a biocompatible polymer formed from;

a) hydroxyethylmethacrylate monomers, or vinyl alcohol monomers, or hydroxyethylmethacrylate monomers and vinyl alcohol monomers; and

b) aromatic amine monomers;

2) a solvent; and

3) a visualization agent;

wherein the biocompatible polymer is soluble in the solvent and insoluble at physiological conditions; and

wherein the visualization agent is integrated into or associated with the biocompatible polymer, and the visualization agent is triiodophenol-lactide-glycolide (TIP).

2. The composition of claim 1, wherein the physiological conditions include contact with a physiological fluid including blood, urine, saliva, mucous, vaginal fluid, seminal fluid, cerebral spinal fluid, sweat, plasma, bile, stomach acid, intestinal fluids, or a combination thereof.

3. The composition of claim 2, wherein the physiological fluid has a pH of about 7.0.

4. The composition of claim 2, wherein the physiological fluid has a pH of between about 7.0 and about 7.8.

5. The composition of claim 1, wherein the solvent is a water miscible organic solvent.

6. The composition of claim 1, wherein the aromatic amine monomer includes an amino group which is about 90% positively charged at a pH of 5 and about 10% positively charged at a pH of 7.

7. The composition of claim 1, wherein the biocompatible polymer comprises hydroxyethylmethacrylate, polyvinyl pyridine (PVP), 1-vinylimidazole, 4-vinylpyridine, or a combination thereof.

8. The composition of claim 1, wherein the biocompatible polymer includes about 60% w/w HEMA and the visualization agent includes about 40% w/w TIP.

9. The composition of claim 1, wherein the biocompatible polymer includes about 15% w/w HEMA and the visualization agent includes about 85% w/w TIP.

10. The composition of claim 1, wherein the solvent is water or a co-solvent of water and dimethyl sulfoxide (DMSO).

11. The composition of claim 1, wherein the biocompatible polymer is formed from hydroxyethylmethacrylate monomers and aromatic amine monomers.