Method of treating renal system damage

• US 10,369,125 B2
• Filed: 04/20/2017
• Issued: 08/06/2019
• Est. Priority Date: 06/19/2008
• Status: Active Grant

• Current Assignee: University of Utah Research Foundation (State of Utah)
• Original Assignee: University of Utah Research Foundation (State of Utah)
• Inventors: Yang, Tianxin
• Primary Examiner(s): Heyer, Dennis
• Application Number:
  US15/492,732
• Publication Number:
  US 20180092873A1
• Time in Patent Office: 838 Days
• Field of Search: None
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/201 having one or two double bonds, e.g. oleic, linoleic acids
• CPC Class Codes: A61K 31/231 having one or two double bonds
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Methods of treating the side effects of a toxic medical therapy using nitrated lipids are disclosed herein. In particular, the methods comprise the use of nitrated fatty acids or esters thereof to treat side effects, including organ system damage, caused by chemotherapy, radiotherapy, and the administration of other toxic agents.

Claims

1. A method of treating renal system damage in a subject, comprising:

administering to the subject an effective amount of a nitrated fatty acid,

wherein the renal system damage is selected from the group consisting of distortion of the overall renal morphology, appearance of protein cast, oxidative stress, and apoptosis of organ cells; and

wherein the nitrated fatty acid is 10-nitro oleic acid.

2. The method of claim 1, wherein the renal system damage is distortion of the overall renal morphology.

3. The method of claim 1, wherein the renal system damage is appearance of protein cast.

4. The method of claim 1, wherein the renal system damage is oxidative stress.

5. The method of claim 2, wherein the renal system damage is apoptosis of organ cells.