Method and apparatus for treatment of respiratory disorders

• US 10,369,310 B2
• Filed: 03/05/2014
• Issued: 08/06/2019
• Est. Priority Date: 03/05/2014
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Inventors: Ramanan, Dinesh, Armitstead, Jeffrey Peter, Hwang, Joon-Pil, Mchenry, Jane Zona, Row, Nathan John
• Primary Examiner(s): Merene, Jan Christopher L
• Assistant Examiner(s): Boecker, Joseph D.
• Application Number:
  US14/197,745
• Publication Number:
  US 20150250963A1
• Time in Patent Office: 1,980 Days
• CPC Class Codes: A61M 16/0003 Accessories therefor, e.g. sensors, vibrators, negative pressure
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/0683 Holding devices therefor
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3365 Rotational speed
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3561 local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3584 using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2230/40 Respiratory characteristics
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: A61M 2230/435 : partial O2 pressure (P-O2)
• CPC Class Codes: A61M 2230/63 : Motion, e.g. physical activity

Abstract

Disclosed is an apparatus for treating a respiratory disorder. The apparatus comprises a pressure device, and a controller, including at least one processor, configured to control the pressure device to: supply, upon initiation of treatment, a flow of pressurized air to the airway of a patient at a treatment pressure according to a pre-sleep profile of pressure versus time, increase, upon detection of sleep onset of the patient, the treatment pressure to a predetermined therapeutic pressure according to a bridging profile of pressure versus time, and supply the flow of pressurized air to the airway of the patient at a therapeutic pressure.

Claims

1. Apparatus for treating a respiratory disorder comprising:

a pressure device, and

a controller, including at least one processor, configured to control the pressure device to;

supply, upon initiation of treatment, a flow of pressurised air to the airway of a patient at a treatment pressure according to a pre-sleep profile of pressure versus time,

increase, upon detection of sleep onset of the patient, the treatment pressure to a predetermined therapeutic pressure according to a bridging profile of pressure versus time, and

supply the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the controller is configured to detect the sleep onset by detecting;

few or no respiratory disturbances occurring within a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the controller detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.

2. Apparatus according to claim 1 wherein the pre-sleep profile is determined by the processor according to a pre-sleep time parameter, and wherein the bridging profile is determined by the processor according to a bridging time parameter, and wherein the bridging time parameter is substantially shorter than the pre-sleep time parameter.

3. Apparatus according to claim 2, wherein the pre-sleep profile is a constant value equal to a pre-sleep pressure for a duration equal to the pre-sleep time parameter, and wherein the controller is configured to make the detection of the sleep onset during application of the constant value of the pre-sleep profile.

4. Apparatus according to claim 2, wherein the pre-sleep profile is a linear increase, with slope chosen such that the pressure would reach the predetermined therapeutic pressure at the pre-sleep time parameter in the absence of sleep onset detection.

5. Apparatus according to claim 2, wherein the pre-sleep profile is a series of linear increases separated by pause periods during which the pressure is constant, wherein a slope and duration of the linear increases and a pause period duration are chosen such that the pressure would reach the predetermined therapeutic pressure at the pre-sleep time parameter in the absence of sleep onset detection.

6. Apparatus according to claim 2, wherein the bridging profile is a linear increase, with slope chosen such that the pressure reaches the predetermined therapeutic pressure at the bridging time parameter.

7. Apparatus according to claim 2, wherein the bridging profile is a series of linear increases separated by pause periods during which the pressure is constant, wherein the slope and duration of the linear increases and the pause period duration are chosen such that the pressure reaches the predetermined therapeutic pressure at the bridging time parameter.

8. Apparatus according to claim 1, wherein the pre-sleep profile is determined by the processor according to a pre-sleep slope, the bridging profile is determined by the processor according to a bridging slope, and wherein the bridging slope is substantially higher than the pre-sleep slope.

9. Apparatus according to claim 8, wherein the pre-sleep profile is a constant value equal to a pre-sleep pressure.

10. Apparatus according to claim 8, wherein the pre-sleep profile is a linear increase of slope equal to the pre-sleep slope.

11. Apparatus according to claim 8, wherein the pre-sleep profile is a series of linear increases separated by pause periods during which the pressure is constant, wherein the slope of the linear increases is equal to the pre-sleep slope.

12. Apparatus according to claim 8, wherein the pre-sleep profile is a series of linear increases that coincide with inspiratory portions of each breathing cycle, separated by pause periods that coincide with expiratory portions of each breathing cycle during which the pressure is held constant, wherein the slope of the linear increases is equal to the pre-sleep slope.

13. Apparatus according to claim 8, wherein the bridging profile is a linear increase, of slope equal to the bridging slope.

14. Apparatus according to claim 8, wherein the bridging profile is a series of linear increases separated by pause periods during which the pressure is constant, wherein the slope of the linear increases is equal to the bridging slope.

15. Apparatus according claim 8, wherein the bridging profile is a series of linear increases that coincide with inspiratory portions of each breathing cycle, separated by pause periods that coincide with expiratory portions of each breathing cycle during which the pressure is held constant, wherein the slope of the linear increases is equal to the bridging slope.

16. Apparatus according to claim 1, wherein the controller is further configured to control the pressure device to increase the treatment pressure to the predetermined therapeutic pressure according to the bridging profile upon expiry of a predetermined timer limit.

17. Apparatus according to claim 1, wherein the therapeutic pressure is the predetermined therapeutic pressure.

18. Apparatus according to claim 1, wherein the therapeutic pressure varies according to occurrences of sleep disordered breathing events.

31. The apparatus of claim 1 wherein the controller is further configured to detect sleep onset by detecting multiple occurrences of sleep disordered breathing events within a second predetermined interval, the second predetermined interval being a second predetermined time or second predetermined breath count.

32. The apparatus of claim 1 wherein the controller detects few or no respiratory disturbances by testing lack of variation during the predetermined interval of one or more of (a) tidal volume, (b) inspiratory time, (c) respiratory rate, (d) inspiratory peak flow, and (e) time since last breath.

33. The apparatus of claim 32 wherein the predetermined interval is the predetermined time and the predetermined time is in a range of two to nine minutes.

34. The apparatus of claim 32 wherein the predetermined interval is the predetermined breath count and the predetermined breath count is in a range of ten to fifty breaths.

19. A method of treating a respiratory disorder, the method comprising:

supplying, upon initiation of treatment, a flow of pressurised air from a pressure device to the airway of a patient at a treatment pressure according to a pre-sleep profile of pressure versus time,

increasing, upon detection of sleep onset of the patient by a controller of the pressure device, the treatment pressure to a predetermined therapeutic pressure according to a bridging profile of pressure versus time, and

supplying the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the controller of the pressure device is configured to detect the sleep onset by detecting;

few or no respiratory disturbances occurring within a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the controller detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.

20. Apparatus for treating a respiratory disorder comprising:

a pressure device, and

a controller, including at least one processor, configured to control the pressure device to;

supply, upon initiation of treatment, a flow of pressurised air to the airway of a patient at a treatment pressure that commences at a pre-sleep pressure and varies according to occurrences of sleep disordered breathing events,

increase, upon detection of sleep onset of the patient, the treatment pressure to a predetermined therapeutic pressure according to a bridging profile of pressure versus time, and

supply the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the controller is configured to detect the sleep onset by detecting;

few or no respiratory disturbances occurring within a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the controller detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.

21. Apparatus according to claim 20, wherein the controller is further configured to control the pressure device to increase the treatment pressure to the predetermined therapeutic pressure according to the bridging profile upon expiry of a predetermined timer limit.

22. Apparatus according to claim 20, wherein the controller is further configured to control the pressure device to increase the treatment pressure to the predetermined therapeutic pressure according to the bridging profile upon the treatment pressure reaching the predetermined therapeutic pressure.

23. Apparatus according to claim 20, wherein the treatment pressure varies according to occurrences of sleep disordered breathing events such that the treatment pressure is prevented from decreasing.

24. Apparatus according to claim 20, wherein the treatment pressure varies according to occurrences of sleep disordered breathing events between a predetermined pre-sleep pressure and the predetermined therapeutic pressure.

25. A method of treating a respiratory disorder, the method comprising:

supplying, upon initiation of treatment, a flow of pressurised air from a pressure device to the airway of a patient at a treatment pressure that commences at a pre-sleep pressure and varies according to occurrences of sleep disordered breathing events,

increasing, upon detection of sleep onset of the patient by a controller of the pressure device, the treatment pressure to a predetermined therapeutic pressure according to a bridging profile of pressure versus time, and

supplying the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the controller of the pressure device to provide the increasing treatment pressure is configured to detect the sleep onset by detecting;

few or no respiratory disturbances occurring within a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the controller detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.

26. Apparatus for treating a respiratory disorder comprising:

a pressure device, and

a controller, including at least one processor, configured to control the pressure device to;

supply, upon initiation of treatment, a flow of pressurised air to the airway of a patient at a treatment pressure according to a pre-sleep profile of pressure versus time,

adjust, upon detection of sleep onset of the patient, the treatment pressure according to occurrences of sleep disordered breathing events, and

supply, upon the treatment pressure reaching a predetermined therapeutic pressure, the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the processor is configured to detect the sleep onset by detecting;

few or no respiratory disturbances enduring for a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the processor detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.

27. Apparatus according to claim 26, wherein the controller is further configured to control the pressure device to supply the flow of pressurised air to the airway of the patient at the therapeutic pressure upon expiry of a predetermined timer limit.

28. Apparatus according to claim 26, wherein the controller is configured to control the pressure device to adjust the treatment pressure according to occurrences of sleep disordered breathing events such that the treatment pressure is prevented from decreasing.

29. Apparatus according to claim 26, wherein the controller is configured to control the pressure device to adjust the treatment pressure according to occurrences of sleep disordered breathing events below the predetermined therapeutic pressure.

30. A method of treating a respiratory disorder, the method comprising:

supplying, upon initiation of treatment, a flow of pressurised air from a pressure device to the airway of a patient at a treatment pressure according to a pre-sleep profile of pressure versus time,

adjusting, upon detection of sleep onset of the patient by a controller of the pressure device, the treatment pressure according to occurrences of sleep disordered breathing events, and

supplying, upon the treatment pressure reaching a predetermined therapeutic pressure, the flow of pressurised air to the airway of the patient at a therapeutic pressure,

wherein the controller of the pressure device to provide the treatment pressure detects the sleep onset by detecting;

few or no respiratory disturbances occurring within a predetermined interval, the predetermined interval being a predetermined time or predetermined breath count, wherein, by monitoring respiratory flow derived from a flow transducer, the controller detects few or no respiratory disturbances to detect the sleep onset by testing lack of variation during the predetermined interval of expiratory peak flow location.