Enhanced dorsal horn stimulation using multiple electrical fields

• US 10,369,363 B2
• Filed: 02/28/2018
• Issued: 08/06/2019
• Est. Priority Date: 07/24/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A., Hershey, Bradley Lawrence, Zhu, Changfang
• Primary Examiner(s): Stice, Paula J
• Application Number:
  US15/908,005
• Publication Number:
  US 20180185646A1
• Time in Patent Office: 524 Days
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36132 using patient feedback
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/36192 Amplitude modulation

Abstract

A method of providing therapy to a patient having a medical condition comprises delivering electrical stimulation energy to the spinal cord of the patient in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord. The delivered electrical stimulation energy generates a plurality of electrical fields having different orientations that stimulate the dorsal horn neuronal elements.

Claims

1. A non-transitory machine-readable medium including instructions, which when executed by a neuromodulator connected to implanted electrodes which are operably positioned near a spinal cord, cause the neuromodulator to provide a therapy using implanted electrodes to a patient having a medical condition, including deliver electrical energy as a pulsed electrical waveform to the targeted neuronal elements in accordance with a stimulation program that preferentially stimulates the targeted neuronal elements, wherein the pulsed electrical waveform to the targeted neuronal elements produces a first electrical field to the targeted neuronal elements where the first electrical field has a first orientation during at least a first pulse in the pulsed electrical waveform, a second electrical field to the targeted neuronal elements where the second electrical field has a second orientation during at least a second pulse in the pulsed electrical waveform, and a third electrical field to the targeted neuronal elements where the third electrical field has a third orientation during at least a third pulse in the pulsed electrical waveform the first, second and third orientations being different from each other.

2. The non-transitory machine-readable medium of claim 1, wherein the pulsed electrical waveform includes repeating electrical field cycles, wherein each of the repeating electrical field cycles includes the first electrical field, the second electrical field, and the third electrical field.

3. The non-transitory machine-readable medium of claim 2, wherein each of the first electrical field, the second electrical field and the third electrical field within each of the repeating electrical field cycles includes a same number of pulses.

4. The non-transitory machine-readable medium of claim 2, wherein each of the first electrical field, the second electrical field and the third electrical field within each of the repeating electrical field cycles includes a different number of pulses.

5. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated in a same order during the electrical field cycles.

6. The non-transitory machine-readable medium of claim 2, wherein the electrical fields are generated in a different order during the electrical field cycles.

7. The non-transitory machine-readable medium of claim 2, wherein the repeating electrical field cycles are bursted on and off at a burst frequency.

8. The non-transitory machine-readable medium of claim 2, wherein the electrical field cycles include a bias toward one of the first, second or third electrical fields relative to the other ones of the first, second or third electrical fields.

9. The non-transitory machine-readable medium of claim 1, wherein the first, second and third electrical fields are rotated through under a timing scheme.

10. A system for providing a therapy to a patient using electrodes which are implanted operably near a spinal cord, the system comprising a neuromodulator including stimulation output circuitry and a controller/processor, wherein:

the stimulation output circuitry is configured to be electrically connected to the electrodes; and

the controller/processor is configured to cooperate with the stimulation output circuitry to provide the therapy to the patient by delivering electrical stimulation energy as a pulsed electrical waveform using the electrodes in accordance with a stimulation program that preferentially stimulates targeted neuronal elements, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to generate a first electrical field to the targeted neuronal elements where the first field has a first orientation during at least a first pulse in the pulsed electrical waveform, a second electrical field to the targeted neuronal elements where the second field has a second orientation during at least a second pulse in the pulsed electrical waveform, and a third electrical field to the targeted neuronal elements where the third field has a third orientation during at least a third pulse in the pulsed electrical waveform, the first, second and third orientations being different from each other.

11. The system of claim 10, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to provide an electrical field with a longitudinal voltage gradient along the spinal cord that is smaller than a voltage gradient in a transverse direction.

12. The system of claim 10, wherein the first, second and third orientations comprise different medio-lateral directions.

13. The system of claim 10, wherein the controller/processor is configured to cooperate with the stimulation output circuitry to generate the first electrical field using a first current fractionalization, the second electrical field using a second current fractionalization, and the third electrical field using a third current fractionalization, wherein the first, second, and third current fractionalizations are different from each other.

14. A method implemented using a neuromodulator connected to implanted electrodes which are operably positioned near a spinal cord, the method comprising:

using the neuromodulator to provide a therapy to targeted neuronal elements, including using the implanted electrodes to deliver the electrical energy as a pulsed electrical waveform to the targeted neuronal elements in accordance with a stimulation program that preferentially stimulates the targeted neuronal elements, wherein the pulsed electrical waveform provides a first electrical field to the targeted neuronal elements where the first electric field has a first orientation during at least a first pulse in the pulsed electrical waveform, a second electrical field to the targeted neuronal elements where the second electric field has a second orientation during at least a second pulse in the pulsed electrical waveform, and a third electrical field to the targeted neuronal elements where the third electric field has a third orientation during at least a third pulse in the pulsed electrical waveform, and wherein the first, second and third orientations are different from each other.

15. The method of claim 14, further comprising using a first current fractionalization to generate the first electrical field, using a second current fractionalization to generate the second electrical field, and using a third current fractionalization to generate the third electrical field.

16. The method of claim 14, wherein the first, second and third orientations comprise different medio-lateral directions.

17. The method of claim 14, wherein the pulsed electrical waveform produces a longitudinal voltage gradient along the spinal cord that is smaller than a voltage gradient in a transverse direction.

18. The method of claim 14, wherein the first electrical field is generated using a first current fractionalization, the second electrical field is generated using a second current fractionalization, and the third electrical field is generated using a third current fractionalization, wherein the first, second, and third current fractionalizations are different from each other.

19. The method of claim 14, wherein the pulsed electrical waveform includes repeating electrical field cycles, wherein the electrical fields are generated in a same order during the electrical field cycle, and each of the repeating electrical field cycles includes the first electrical field, the second electrical field, and the third electrical field.

20. The method of claim 14, wherein the pulsed electrical waveform includes repeating electrical field cycles, wherein the electrical fields are generated in a different order during the electrical field cycles, and each of the repeating electrical field cycles includes the first electrical field, the second electrical field, and the third electrical field.