Devices and methods to use power spectrum or signal association for pain management

• US 10,369,364 B2
• Filed: 09/21/2018
• Issued: 08/06/2019
• Est. Priority Date: 09/22/2014
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Moffitt, Michael A., Bokil, Hemant
• Primary Examiner(s): Mahmood, Nadia A
• Application Number:
  US16/138,381
• Publication Number:
  US 20190022395A1
• Time in Patent Office: 319 Days
• Field of Search: 607 45, 607 46
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/374 Detecting the frequency distribution of signals, e.g. detecting delta, theta, alpha, beta or gamma waves
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

Methods and systems for electrical stimulation can include obtaining a biosignal of the patient; altering at least one stimulation parameter of an electrical stimulation system in response to the biosignal; and delivering an electrical stimulation current to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter. In some embodiments, a power spectrum is determined from the biosignal. In some embodiments, the biosignal is at least two different biosignals measured at the same or different locations on the patient and a coherence, correlation, or association between the two biosignal is determined.

Claims

1. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue, wherein the implantable control module comprises

a processor configured and arranged to perform the following actions;

obtaining at least two different biosignals of the patient,

determining a measure of association between the at least two different biosignals,

altering at least one stimulation parameter of the electrical stimulation system in response to the measure of association between the at least two different biosignals, and

directing delivery of electrical stimulation signals to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter.

2. The system of claim 1, wherein determining the measure of association comprises determining a measure of coherence between the at least two different biosignals.

3. The system of claim 1, wherein determining the measure of association comprises determining a measure of correlation between the at least two different biosignals.

4. The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining an electroencephalogram of a theta band for the patient and an electroencephalogram of a gamma band for the patient.

5. The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different points in time.

6. The system of claim 1, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different locations on a body of the patient.

7. The system of claim 6, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites.

8. The system of claim 1, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of synchronous activity.

9. The system of claim 8, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites to desynchronize the synchronous activity.

10. The system of claim 1, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of pain.

11. An electrical stimulation system, comprising:

an implantable control module configured and arranged for implantation in a body of a patient and comprising an antenna and a processor coupled to the antenna, wherein the control module is configured and arranged to provide electrical stimulation signals to an electrical stimulation lead coupled to the implantable control module for electrical stimulation of patient tissue; and

an external programming unit configured and arranged to communicate with the processor of the implantable control module using the antenna and to adjust stimulation parameters for production of the electrical stimulation signals, wherein the external programming unit comprises

a processor configured and arranged to perform the following actions;

obtaining at least two different biosignals of the patient,

determining a measure of association between the at least two different biosignals, and

altering at least one stimulation parameter of the electrical stimulation system in response to the measure of association between the at least two different biosignals;

wherein the processor of the implantable control module is configured to direct delivery of electrical stimulation signals to one or more selected electrodes of the electrical stimulation system using the at least one stimulation parameter.

12. The system of claim 11, wherein determining the measure of association comprises determining a measure of coherence between the at least two different biosignals.

13. The system of claim 11, wherein determining the measure of association comprises determining a measure of correlation between the at least two different biosignals.

14. The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining an electroencephalogram of a theta band for the patient and an electroencephalogram of a gamma band for the patient.

15. The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different points in time.

16. The system of claim 11, wherein obtaining the at least two different biosignals of the patient comprises obtaining a same type of biosignal at two different locations on a body of the patient.

17. The system of claim 16, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites.

18. The system of claim 11, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of synchronous activity.

19. The system of claim 18, wherein directing delivery of the electrical stimulation signals comprises directing delivery of the electrical stimulation signals to a plurality of selected electrodes to produce stimulation to different stimulation sites to desynchronize the synchronous activity.

20. The system of claim 11, wherein determining the measure of association comprises determining the measure of association between the at least two different biosignals to determine whether the measure of association is indicative of pain.