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Analyte sensing biointerface

  • US 10,376,188 B2
  • Filed: 09/21/2017
  • Issued: 08/13/2019
  • Est. Priority Date: 04/15/2005
  • Status: Active Grant
First Claim
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1. An implantable continuous glucose sensor system, comprising:

  • a transcutaneous sensor comprising a working electrode configured to measure a signal indicative of a glucose concentration in an interstitial fluid;

    a membrane disposed on the working electrode, wherein the membrane comprises a biointerface, wherein the biointerface comprises;

    a first bioactive agent, wherein the first bioactive agent is configured to reduce effects from inflammation associated with the working electrode, wherein the first bioactive agent is configured to be released during a first time period; and

    a second bioactive agent, wherein the second bioactive agent is different from the first bioactive agent, wherein the second bioactive agent is configured to reduce effects from a continual decline in sensor sensitivity, wherein the second bioactive agent is configured to be released during a second time period, wherein the first time period is different from the second time period, wherein the second time period ends later than the first time period; and

    electronics electrically coupled to the working electrode.

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