Prevention of aortic valve fusion

• US 10,376,622 B2
• Filed: 07/12/2018
• Issued: 08/13/2019
• Est. Priority Date: 02/27/2009
• Status: Active Grant

• Current Assignee: TC1 LLC (Abbott Laboratories Incorporated)
• Original Assignee: TC1 LLC (Abbott Laboratories Incorporated)
• Inventors: Poirier, Victor
• Primary Examiner(s): Hulbert, Amanda K
• Application Number:
  US16/034,129
• Publication Number:
  US 20190001035A1
• Time in Patent Office: 397 Days
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3355 Controlling downstream pump pressure
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/216 including a rotating member acting on the blood, e.g. impeller
• CPC Class Codes: A61M 60/411 generated by an electromotor
• CPC Class Codes: A61M 60/523 using blood flow data, e.g. from blood flow transducers
• CPC Class Codes: A61M 60/531 using blood pressure data, e.g. from blood pressure sensors

Abstract

Materials and methods related to blood pump systems are described. These can be used in patients to, for example, monitor arterial pressure, measure blood flow, maintain left ventricular pressure within a particular range, avoid left ventricular collapse, prevent fusion of the aortic valve in a subject having a blood pump, and provide a means to wean a patient from a blood pump.

Claims

1. A method of controlling a blood pump to facilitate gradual weaning of a patient from the blood pump, the blood pump receiving a flow of blood from a ventricle of the patient and outputting the flow of blood to an artery of the patient, the method comprising:

controlling, by a controller, a speed of the blood pump over a first period of time encompassing multiple contractions of the ventricle to provide circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within a first predetermined range;

subsequent to the first period of time, controlling, by the controller, the speed of the blood pump over a second period of time encompassing multiple contractions of the ventricle to provide a reduced level of circulatory support to the patient relative to the circulatory support provided to the patient over the first period of time;

subsequent to the second period of time, controlling, by the controller, the speed of the blood pump over a third period of time encompassing multiple contractions of the ventricle to provide circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within the first predetermined range; and

determining, by the controller, whether the ventricle provided circulatory support to the patient over the second period of time that exceeded a predetermined minimum level of circulatory support.

2. The method of claim 1, wherein:

the ventricle is a left ventricle of the patient; and

the first predetermined range is between an aortic blood pressure of the patient and about 20 mm Hg below the aortic blood pressure.

3. The method of claim 1, wherein:

the ventricle is a right ventricle of the patient; and

the first predetermined range is between 5 mm Hg and 20 mm Hg.

4. The method of claim 1, wherein:

the blood pump is controlled to pump blood within a first predetermined range of flow rates to provide circulatory support to the patient over the first period of time;

the blood pump is controlled to pump blood at a reduced flow rate over the second period of time relative to the flow rate over the first period of time; and

the blood pump is controlled to pump blood within the first predetermined range of flow rates to provide circulatory support to the patient over the third period of time.

5. The method of claim 4, wherein the reduced flow rate is between about 0.5 liters/minute and 1.5 liters/minute less than a flow rate during the first period of time.

6. The method of claim 1, wherein the reduced level of circulatory support results in systolic blood pressure within the ventricle being maintained at about an arterial blood pressure within the artery.

7. The method of claim 1, wherein the first period of time is at least 5 minutes.

8. The method of claim 1, wherein the second period of time is between 1 and 5 minutes.

9. The method of claim 1, wherein:

the ventricle is a left ventricle of the patient;

the artery is an aorta of the patient; and

the method further comprises controlling, by the controller, the speed of the blood pump to revert from providing the reduced level of circulatory support to the patient to providing circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within the first predetermined range in response to detecting at least one of;

a decrease in aortic blood pressure of at least a first predetermined amount during the second period of time, and

an increase of an end diastolic blood pressure within the left ventricle of at least a second predetermined amount during the second period of time.

10. The method of claim 1, wherein:

the ventricle is a right ventricle of the patient;

the artery is a pulmonary artery of the patient; and

the method further comprises controlling, by the controller, the speed of the blood pump to revert from providing the reduced level of circulatory support to the patient to providing circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within the first predetermined range in response to detecting at least one of;

a decrease in pulmonary artery blood pressure of at least a first predetermined amount during the second period of time, and

an increase of an end diastolic blood pressure within the right ventricle of at least a second predetermined amount during the second period of time.

11. The method of claim 1, wherein the determination of whether the ventricle provided circulatory support to the patient over the second period of time that exceeded the predetermined minimum level of circulatory support comprises determining whether a decrease in blood pressure in the artery of at least a first predetermined amount occurs during the second period of time.

12. The method of claim 11, wherein the determination of whether the ventricle provided circulatory support to the patient over the second period of time that exceeded the predetermined minimum level of circulatory support comprises determining whether an increase of an end diastolic blood pressure within the ventricle of at least a second predetermined amount occurs during the second period of time.

13. The method of claim 1, further comprising:

in response to determining that the ventricle provided circulatory support to the patient over the second period of time that exceeded the predetermined minimum level of circulatory support,

subsequent to the third period of time, controlling, by the controller, the speed of the blood pump over a fourth period of time encompassing multiple contractions of the ventricle to provide a reduced level of circulatory support to the patient relative to the circulatory support provided to the patient over the third period of time, the fourth period of time being greater than the second period of time;

subsequent to the fourth period of time, controlling, by the controller, the speed of the blood pump over a fifth period of time encompassing multiple contractions of the ventricle to provide circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within the first predetermined range; and

determining, by the controller, whether the ventricle provided circulatory support to the patient over the fourth period of time that exceeded the predetermined minimum level of circulatory support.

14. The method of claim 3, further comprising:

in response to determining that the ventricle provided circulatory support to the patient over the fourth period of time that exceeded the predetermined minimum level of circulatory support,

subsequent to the fifth period of time, controlling, by the controller, the speed of the blood pump over a sixth period of time encompassing multiple contractions of the ventricle to provide a reduced level of circulatory support to the patient relative to the circulatory support provided to the patient over the fifth period of time, the sixth period of time being greater than the fourth period of time;

subsequent to the sixth period of time, controlling, by the controller, the speed of the blood pump over a seventh period of time encompassing multiple contractions of the ventricle to provide circulatory support to the patient to maintain a positive level of systolic blood pressure within the ventricle within the first predetermined range; and

determining, by the controller, whether the ventricle provided circulatory support to the patient over the sixth period of time that exceeded the predetermined minimum level of circulatory support.

15. A method of controlling a blood pump to facilitate gradual weaning of a patient from the blood pump, the blood pump receiving a flow of blood from a ventricle of the patient and outputting the flow of blood to an artery of the patient, the method comprising:

receiving, by a controller, an input indicative of a blood pressure within the ventricle; and

controlling, by the controller, a speed of the blood pump such that;

a blood pressure within the ventricle is maintained equal to or greater than a lower threshold for avoiding ventricular collapse, and

the blood pressure within the ventricle is maintained equal to or less than an upper threshold to maintain an end diastolic blood pressure within an acceptable range.

16. The method of claim 15, wherein:

the ventricle is a left ventricle;

the lower threshold is within a range from 10 mm Hg to 40 mm Hg; and

the upper threshold is within a range from 65 mm Hg to about a blood pressure within an aorta of the patient.

17. The method of claim 15, wherein:

the ventricle is a right ventricle;

the lower threshold within a range from 5 mm Hg to 20 mm Hg; and

the upper threshold is within a range from 20 mm Hg to about 60 mm Hg.