Flexible biological fluid filters

• US 10,376,627 B2
• Filed: 06/06/2014
• Issued: 08/13/2019
• Est. Priority Date: 03/24/2014
• Status: Active Grant

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Inventors: Verri, Paolo, Lynn, Daniel, Day, Scott
• Primary Examiner(s): Gonzalez, Madeline
• Application Number:
  US15/127,042
• Publication Number:
  US 20170136167A1
• Time in Patent Office: 1,894 Days
• Field of Search: 210450, 210645, 210782, 210 94, 210499, 210335, 210488-490
• CPC Class Codes: A61M 1/0281 Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing
• CPC Class Codes: A61M 1/3636 having a flexible housing
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes lymphocytes A61M2202/0407
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: Y10T 156/10 Methods of surface bonding and/or assembly therefor

Abstract

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls. A filtration medium and a support member are at least partially positioned between the walls of the housing, with a seal joining the walls of the housing, the filtration medium, and the support member. The filter assemblies may further include a pre-filter and/or a post-filter positioned between the walls of the housing. If provided, the pre- and post-filter may be positioned on opposite walls of the filtration medium, with the post-filter being a mesh positioned between the filtration medium and one of the walls of the housing or within an opening defined by the support member. A seal of the filter assembly may pass through the filtration medium, with the filtration medium being substantially omitted in a section of the seal.

Claims

1. A biological fluid filter assembly comprising:

a flexible housing having first and second walls;

a filtration medium at least partially positioned between the first and second walls of the housing;

a substantially planar post-filter mesh at least partially positioned between the filtration medium and the second wall, the post-filter mesh comprising a semi-permeable layer with material present in a grid or web or crossed arrangement defining a plurality of voids without woven or overlapping strands or strips of material and having a normalized air permeability at a pressure difference of 125 Pa in the range of approximately 40 to approximately 800 cm²/s; and

a seal joining the first and second walls of the housing.

2. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a normalized air permeability at a pressure difference of 125 Pa of approximately 81.5 cm²/s.

3. The biological fluid filter assembly of claim 1, wherein the seal joins the first and second walls of the housing and the post-filter mesh.

4. The biological fluid filter assembly of claim 1, further comprising a frame positioned between the filtration medium and the second wall, wherein the post-filter mesh is integrally formed with the frame.

5. The biological fluid filter assembly of claim 4, wherein the seal joins the first and second walls of the housing and the frame.

6. The biological fluid filter assembly of claim 5, wherein

the frame is comprised of the same material as the second wall, and

the frame and the second wall are melted together in at least a portion of the seal.

7. The biological fluid filter assembly of claim 1, further comprising a pre-filter at least partially positioned between the filtration medium and the first wall of the housing, wherein the seal joins the first and second walls of the housing and the pre-filter.

8. The biological fluid filter assembly of claim 1, wherein the post-filter mesh is formed of a plastic material.

9. The biological fluid filter assembly of claim 1, wherein the post-filter mesh is formed of a polyvinyl chloride material.

10. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a varying thickness.

11. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a generally uniform thickness.

12. The biological fluid filter assembly of claim 1, wherein the voids each have a shape selected from the group consisting of rectangular, square, and diamond-shaped.

13. The biological fluid filter assembly of claim 1, wherein at least two of said voids are differently configured.

14. The biological fluid filter assembly of claim 1, wherein the voids each have a height and width in the range of approximately 0.5-20 mm.

15. The biological fluid filter assembly of claim 1, wherein the voids each have a thickness in the range of approximately 0.5-4 mm.

16. The biological fluid filter assembly of claim 1, wherein the voids are arranged in a uniform pattern.

17. The biological fluid filter assembly of claim 1, wherein the voids are arranged in a non-uniform pattern.

18. The biological fluid filter assembly of claim 1, wherein the post-filter mesh is free-floating with respect to the first and second walls, the filtration medium, and the seal.

19. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a normalized air permeability at a pressure difference of 125 Pa in the range of approximately 50 to approximately 400 cm²/s.

20. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a normalized air permeability at a pressure difference of 125 Pa in the range of approximately 70 to approximately 150 cm²/s.

21. The biological fluid filter assembly of claim 1, wherein the post-filter mesh has a generally uniform porosity or permeability.

22. The biological fluid filter assembly of claim 1, wherein the post-filter mesh comprises a molded component.

23. The biological fluid filter assembly of claim 1, wherein the post-filter mesh is configured to allow generally uniform flow therethrough.