System to estimate the location of a spinal cord physiological midline

• US 10,376,702 B2
• Filed: 03/23/2017
• Issued: 08/13/2019
• Est. Priority Date: 04/04/2016
• Status: Active Grant

• Current Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Neuromodulation Corporation (Boston Scientific Corporation)
• Inventors: Serrano Carmona, Raul, Hershey, Bradley
• Primary Examiner(s): Bockelman, Mark
• Application Number:
  US15/467,416
• Publication Number:
  US 20170281959A1
• Time in Patent Office: 873 Days
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/08 Arrangements or circuits for monitoring, protecting, controlling or indicating for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

Techniques for determining the location of a physiological midline are disclosed. A first technique evaluates the response to stimulation of spinal electrodes at peripheral electrodes on different sides of the body. In this technique, a spinal electrode'"'"'s position relative to a physiological midline is determined based on a relationship between responses to its stimulation observed on different sides of the body. A second technique evaluates the response of spinal electrodes to stimulation of peripheral electrodes on different sides of the body. In this technique, a spinal electrode'"'"'s position relative to a physiological midline is determined based on the different responses that it observes to stimulation on different sides of the body.

Claims

1. A system comprising:

one or more leads implantable in a patient, each of the one or more leads comprising one or more spinal electrodes; and

an external device comprising a non-transitory computer-readable medium, comprising instructions, which when executed by a control circuitry of the external device, configure the control circuitry to;

send instructions to a stimulation device to provide electrical stimulation at a first one or more peripheral electrodes that are positionable on a first side of an anatomical midline of the patient and to a second one or more peripheral electrodes that are positionable on a second side of an anatomical midline of the patient;

receive data from the one or more leads that is indicative of a response at the one or more spinal electrodes to the electrical stimulation provided at the first and second one or more peripheral electrodes; and

calculate, based on the received data, a ratio of the responses at the one or more spinal electrodes to the electrical stimulation provided at the first and second one or more peripheral electrodes, and

calculate, based on the ratio, a measure of each of the one or more spinal electrodes'"'"' position with respect to a physiological midline.

2. The system of claim 1, wherein the measure of each spinal electrode'"'"'s position with respect to the physiological midline indicates a side of the physiological midline on which the spinal electrode is located.

3. The system of claim 1, wherein the instructions further cause the control circuitry to determine a location of each of the one or more spinal electrodes.

4. The system of claim 3, wherein the instructions further cause the control circuitry to calculate a contribution to a physiological midline location for each spinal electrode based on the spinal electrode'"'"'s location and the measure of the spinal electrode'"'"'s position with respect to the physiological midline.

5. The system of claim 4, wherein the instructions to calculate the contribution to the physiological midline location comprise instructions to determine a correlation between the measure of the one or more spinal electrodes'"'"' positions with respect to the physiological midline and a distance from the midline.

6. The system of claim 5, wherein the non-transitory computer readable medium further comprises instructions to determine the correlation comprise instructions to iteratively update a correlation value.

7. The system of claim 4, wherein the non-transitory computer readable medium further comprises instructions to determine a location of the physiological midline based on the contributions of the one or more spinal electrodes.

8. The system of claim 7, wherein the instructions further cause the control circuitry to display the location of the physiological midline on a graphical user interface.

9. The system of claim 1, wherein the non-transitory computer readable medium further comprises instructions to cause the control circuitry to calculate a location of the physiological midline.

10. The system of claim 9, wherein the non-transitory computer readable medium further comprises instructions to cause the control circuitry to display the location of the physiological midline on a graphical user interface.

11. The system of claim 10, wherein the instructions to display the location of the physiological midline comprise instructions to display the location over an anatomical image.

12. The system of claim 1, wherein the instructions to receive data that is indicative of the response to the electrical stimulation comprise instructions to receive the data from a device coupled to the one or more implanted electrode leads.

13. The system of claim 12, wherein the device coupled to the one or more implanted electrode leads is a pulse generator implanted within the patient.

14. The system of claim 12, wherein the device coupled to the one or more implanted electrode leads is an external monitoring device.

15. The system of claim 1, wherein the instructions to the stimulation device comprise instructions to provide electrical stimulation on corresponding pairs of peripheral electrodes on each side of the anatomical midline.

16. The system of claim 15, wherein the instructions to the stimulation device comprise instructions to proceed sequentially through the corresponding pairs.

17. A system, comprising:

one or more leads implantable in a patient, each of the one or more leads comprising one or more spinal electrodes,

a display;

a memory;

control circuitry; and

a non-transitory computer-readable medium, comprising instructions, which when executed by the control circuitry, cause the control circuitry to;

send instructions to a stimulation device to provide electrical stimulation at a plurality of corresponding pairs of peripheral electrodes, wherein the corresponding pairs of peripheral electrodes each comprise peripheral electrodes positionable on opposite sides of an anatomical midline of a patient;

receive data from the one or more leads that is indicative of a response at the one or more spinal electrodes to the electrical stimulation provided at the one or more pairs of peripheral electrodes; and

calculate, based on the received data, a ratio of the response to electrical stimulation provided on opposite sides of the anatomical midline, and

calculate, based on the ratio, a measure of each of the one or more spinal electrodes'"'"' position with respect to a physiological midline.

18. The system of claim 17, wherein the measure of each spinal electrode'"'"'s position with respect to the physiological midline indicates a side of the physiological midline on which the spinal electrode is located.