Microneedle arrays formed from polymer films
First Claim
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1. A method of manufacturing a transdermal drug delivery device having a microneedle array, comprising:
- providing a substrate;
applying a polymer solution to the substrate to form a base layer;
disposing an exposed surface of the base layer with a textured surface having elevated points protruding therefrom such that the elevated points contact the exposed surface of the base layer;
distancing the textured surface from the exposed surface of the base layer such that the elevated points draw out tube-like projections from the exposed surface of the base layer, wherein the textured surface is distanced from the exposed surface of the base layer at a rate of about 0.1 mm/s to about 100 mm/s;
drying the base layer having the tube-like projections to form microneedles, wherein drying includes exposing the base layer to reduced pressure; and
trimming the microneedles to a predetermined length and tip-bevel to form the transdermal drug delivery device.
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Abstract
The present invention provides for transdermal delivery devices having microneedle arrays, as well as methods for their manufacture and use. In one embodiment, a transdermal delivery device is provided. The transdermal delivery device includes a polymer layer which has microneedles projecting from one of its surfaces. The microneedles are compositionally homogenous with the polymer base layer.
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Citations
14 Claims
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1. A method of manufacturing a transdermal drug delivery device having a microneedle array, comprising:
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providing a substrate; applying a polymer solution to the substrate to form a base layer; disposing an exposed surface of the base layer with a textured surface having elevated points protruding therefrom such that the elevated points contact the exposed surface of the base layer; distancing the textured surface from the exposed surface of the base layer such that the elevated points draw out tube-like projections from the exposed surface of the base layer, wherein the textured surface is distanced from the exposed surface of the base layer at a rate of about 0.1 mm/s to about 100 mm/s; drying the base layer having the tube-like projections to form microneedles, wherein drying includes exposing the base layer to reduced pressure; and trimming the microneedles to a predetermined length and tip-bevel to form the transdermal drug delivery device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification