Biofilm inhibiting compositions enhancing weight gain in livestock
First Claim
1. A method for the treatment or prophylaxis of a microbial infection or colonization in a human, the method comprising administering to the human—
- an effective amount of a composition comprising one or more Fe III complexes to reduce enteropathogen infection in the human, wherein the Fe III complex is a compound of Formula I;
Fe(III)x(ligand)y
Formula I,whereinx is an integer value of 1-2,y is an integer value of 1-3 andwherein the Fe III complexes comprise Fe III and one or more ligands,wherein each ligand is independently a conjugate base of an α
-hydroxy acid selected from citric acid, tartaric acid, lactic acid, glycolic acid, quinic acid, glycolic acid, isoleucic acid, valic acid, malic acid, and mandelic acid;
or each ligand is a conjugate base of an amino acid independently selected from the group consisting of glycine, alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine; and
salts and/or hydrates thereof,and wherein at least one of the one or more Fe III complexes is in a concentrations ranging from 10 μ
M to 2 mM or 0.01 g/Kg of product to 20 g/Kg of product.
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Abstract
A method of enhancing the growth of an animal, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron center such as amino acids or α-hydroxy acids. The compounds are also useful for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
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Citations
10 Claims
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1. A method for the treatment or prophylaxis of a microbial infection or colonization in a human, the method comprising administering to the human—
- an effective amount of a composition comprising one or more Fe III complexes to reduce enteropathogen infection in the human, wherein the Fe III complex is a compound of Formula I;
Fe(III)x(ligand)y
Formula I,wherein x is an integer value of 1-2, y is an integer value of 1-3 and wherein the Fe III complexes comprise Fe III and one or more ligands, wherein each ligand is independently a conjugate base of an α
-hydroxy acid selected from citric acid, tartaric acid, lactic acid, glycolic acid, quinic acid, glycolic acid, isoleucic acid, valic acid, malic acid, and mandelic acid;or each ligand is a conjugate base of an amino acid independently selected from the group consisting of glycine, alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine; and
salts and/or hydrates thereof,and wherein at least one of the one or more Fe III complexes is in a concentrations ranging from 10 μ
M to 2 mM or 0.01 g/Kg of product to 20 g/Kg of product.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
- an effective amount of a composition comprising one or more Fe III complexes to reduce enteropathogen infection in the human, wherein the Fe III complex is a compound of Formula I;
Specification