Modified FGF-21 polypeptides comprising non-naturally encoding amino acids and their uses
First Claim
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1. A composition comprising a pharmaceutically acceptable carrier and a modified FGF-21 polypeptide comprising a non-naturally encoded amino acid, wherein:
- (a) the modified FGF-21 polypeptide comprises a sequence at least 90% identical to SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, or SEQ ID NO;
7;
(b) the non-naturally encoded amino acid has the structure;
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Abstract
Modified FGF-21 polypeptides and uses thereof are provided.
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Citations
21 Claims
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1. A composition comprising a pharmaceutically acceptable carrier and a modified FGF-21 polypeptide comprising a non-naturally encoded amino acid, wherein:
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(a) the modified FGF-21 polypeptide comprises a sequence at least 90% identical to SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, or SEQ ID NO;
7;(b) the non-naturally encoded amino acid has the structure; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A composition comprising a pharmaceutically acceptable carrier and a modified FGF-21 polypeptide comprising a non-naturally encoded amino acid, wherein:
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(a) the modified FGF-21 polypeptide comprises a sequence at least 95% identical to SEQ ID NO;
1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, or SEQ ID NO;
7;(b) the non-naturally encoded amino acid has the structure; - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A composition comprising a pharmaceutically acceptable carrier and a modified FGF-21 polypeptide, wherein:
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(a) said modified FGF-21 polypeptide comprises the polypeptide of SEQ ID NO;
1 except that an amino acid in the modified FGF-21 polypeptide is substituted by a non-naturally encoded amino acid at position 108 of SEQ ID NO;
1;(b) said non-naturally encoded amino acid comprises para-acetyl phenylalanine linked to a polymer comprising a poly(ethylene glycol), wherein said poly(ethylene glycol) has an average molecular weight of about 30 kDa; and (c) said non-naturally encoded amino acid is linked to said polymer through an oxime linkage. - View Dependent Claims (18, 19, 20, 21)
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Specification