Methods for detection of respiratory effort and sleep apnea monitoring devices

• US 10,383,570 B2
• Filed: 07/31/2015
• Issued: 08/20/2019
• Est. Priority Date: 11/07/2012
• Status: Active Grant

• Current Assignee: Koninklijke Philips N.V.
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Parfenova, Maria A., Parfenov, Alexandr S., Zobnin, Yuri P., Konstantinov, Nikolay V.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): Catina, Michael A
• Application Number:
  US14/815,732
• Publication Number:
  US 20160120465A1
• Time in Patent Office: 1,481 Days
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 2562/16 Details of sensor housings or probes; Details of structural supports for sensors A61B2560/0462 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/6819 Nose
• CPC Class Codes: A61B 5/688 using adhesives
• CPC Class Codes: A61B 5/725 using specific filters therefor, e.g. Kalman or adaptive filters A61B5/316 take precedence
• CPC Class Codes: A61B 5/7257 using Fourier transforms

Abstract

A sleep apnea diagnostic system includes a housing that is configured to be attached to near the nose of a patient'"'"'s face to sense physiological information of a patient. The housing includes sensors to sense the physiological information. The physiological information may be, for example, air flow through the nose or the mouth or both. The physiological information further may be, for example, blood volume. The sleep apnea diagnostic system includes at least one processor in the housing or external to the housing or both to analyze the physiological information to determine whether the patient has experienced irregular or abnormal respiratory activity and to detect respiratory effort. The analysis may be real time or delayed.

Claims

1. A sleep apnea monitoring device comprising:

a housing shaped to fit the contours of a patient'"'"'s face;

one or more photosensors positioned on a nasal area of the patient and coupled to the housing, the one or more photosensors configured to generate output signals related to peripheral photoplethysmography data of the patient;

one or more air-flow sensors positioned near or inside one or more nostrils of the patient and coupled to the housing, the one or more air-flow sensors configured to generate output signals conveying airflow information related to an airflow of the patient;

a memory disposed in the housing and configured to store physiological information related to the peripheral photoplethysmography data and store the airflow information; and

one or more processors disposed in the housing and configured to;

receive, from the one or more photosensors, the peripheral photoplethysmography data;

receive, from the one or more air-flow sensors, the airflow information;

identify an apneic event based on the airflow information being indicative of an absence of airflow;

obtain, via filtering of the peripheral photoplethysmography data, a DC component of the peripheral photoplethysmography data;

determine, based on the peripheral photoplethysmography data, a change in vascular tone from a time prior to the apneic event to a time during the apneic event;

determine whether the DC component indicates respiratory effort from the patient; and

responsive to the DC component indicating no respiratory effort from the patient, determine a diagnosis of the apneic event based on an adjusted component, the adjusted component being based on the DC component and the change in vascular tone.

2. The sleep apnea device of claim 1, wherein the one or more processors are configured to:

determine an effect of vasoconstriction on the DC component based on the change in vascular tone;

subtract the effect of vasoconstriction from the DC component to obtain an adjusted component;

determine a respiratory effort of the patient based on the adjusted component; and

use the respiratory effort determined based on the adjusted component to determine the diagnosis of the apneic event.

3. The sleep apnea device of claim 1, wherein the one or more processors are configured to:

responsive to the DC component indicating no respiratory effort from the patient, perform the following operations;

subtracting an effect of vasoconstriction from the DC component to obtain an adjusted component, the effect of vasoconstriction being (i) an effect on the DC component and (ii) based on the change in vascular tone;

determining a respiratory effort of the patient based on the adjusted component; and

using the respiratory effort determined based on the adjusted component to determine the diagnosis of the apneic event.

4. The sleep apnea device of claim 1, wherein the housing is shaped to fit the skin surface of the patient'"'"'s nose, upper lip, and the area of maxillary sinuses.

5. The sleep apnea device of claim 1, wherein the housing further comprises an adhesive on a surface thereof configured to be affixed to the patient'"'"'s skin.

6. The sleep apnea device of claim 1, wherein the housing is made of a flexible bio-compatible polymer.

7. The sleep apnea device of claim 1, wherein the one or more photosensors comprise photo-emitters, and wherein the photo-emitters are disposed on opposite sides of the patient'"'"'s nose.

8. The sleep apnea device of claim 1, wherein the housing further comprises a power source configured to provide power during at least a monitoring period.

9. The sleep apnea device of claim 1, wherein the one or more processors are configured to apply a low-pass filter to the peripheral photoplethysmography data to obtain the DC component of the peripheral photoplethysmography data.

10. The sleep apnea device of claim 1, wherein the housing includes tubing that protrudes from the housing and having a distal end mounted to the one or more air-flow sensors.

11. A method for generating apneic event diagnosis based on specifically-positioned sensors, the method comprising:

affixing a housing on an individual'"'"'s skin;

receiving, with one or more processors, from one or more first sensors, output signals related to peripheral photoplethysmography data of the individual, the one or more first sensors being positioned on a nasal area of the individual and coupled to the housing;

receiving, with the one or more processors, from one or more second sensors, output signals conveying airflow information related to an airflow of the individual, the one or more second sensors being positioned near or inside one or more nostrils of the individual and coupled to the housing;

identifying, with the one or more processors, an apneic event based on the airflow information being indicative of an absence of airflow;

obtaining, via filtering of the peripheral photoplethysmography data, a DC component of the peripheral photoplethysmography data;

determining, with the one or more processors, based on the peripheral photoplethysmography data, a change in vascular tone from a time prior to the apneic event to a time during the apneic event;

determining, with the one or more processors, whether the DC component indicates respiratory effort from the patient; and

responsive to the DC component indicating no respiratory effort from the patient, determining, with the one or more processors, a diagnosis of the apneic event based on an adjusted component, the adjusted component being based on the DC component and the change in vascular tone.

12. The method of claim 11, further comprising:

determining an effect of vasoconstriction on the DC component based on the change in vascular tone;

subtracting the effect of vasoconstriction from the DC component to obtain an adjusted component;

determining a respiratory effort of the patient based on the adjusted component; and

using the respiratory effort determined based on the adjusted component to determine the diagnosis of the apneic event.

13. The method of claim 11, further comprising:

responsive to the DC component indicating no respiratory effort from the patient, performing the following operations;

subtracting an effect of vasoconstriction from the DC component to obtain an adjusted component, the effect of vasoconstriction being (i) an effect on the DC component and (ii) based on the change in vascular tone;

determining a respiratory effort of the patient based on the adjusted component; and

using the respiratory effort determined based on the adjusted component to determine the diagnosis of the apneic event.

14. The method of claim 11, wherein the housing is shaped to fit the skin surface of the individual'"'"'s nose, upper lip, and the area of maxillary sinuses.

15. The method of claim 11, wherein the one or more first sensors comprise photo-emitters, and wherein the photo-emitters are disposed on opposite sides of the individual'"'"'s nose.

16. The method of claim 11, wherein obtaining the DC component comprises applying a low-pass filter to the peripheral photoplethysmography data to obtain the DC component of the peripheral photoplethysmography data.

17. A system for generating apneic event diagnosis based on specifically-positioned sensors, the system comprising:

one or more first sensors positioned on a nasal area of an individual, the one or more first sensors configured to generate output signals related to peripheral photoplethysmography data of the individual;

one or more second sensors positioned near or inside one or more nostrils of the individual, the one or more second sensors configured to generate output signals conveying airflow information related to an airflow of the individual; and

one or more processors configured by machine-readable instructions to;

receive, from the one or more first sensors, the peripheral photoplethysmography data;

receive, from the one or more second sensors, the airflow information;

identify an apneic event based on the airflow information being indicative of an absence of airflow;

obtain a DC component of the peripheral photoplethysmography data;

determine, based on the peripheral photoplethysmography data, a change in vascular tone from a time prior to the apneic event to a time during the apneic event;

determine whether the DC component indicates respiratory effort from the patient; and

responsive to the DC component indicating no respiratory effort from the patient, determine a diagnosis of the apneic event based on an adjusted component, the adjusted component being the DC component and the change in vascular tone.

18. The system of claim 17, wherein the one or more processors are configured to:

responsive to the DC component indicating no respiratory effort from the patient, perform the following operations;

subtracting an effect of vasoconstriction from the DC component to obtain an adjusted component, the effect of vasoconstriction being (i) an effect on the DC component and (ii) based on the change in vascular tone;

determining a respiratory effort of the patient based on the adjusted component; and

using the respiratory effort determined based on the adjusted component to determine the diagnosis of the apneic event.