Systems and methods to infer brain state during burst suppression
First Claim
1. A system for monitoring a subject, the system comprising:
- a plurality of electroencephalogram (EEG) sensors configured to acquire EEG signals from multiple locations about a subject'"'"'s brain;
an input configured to receive at least the EEG signals from the plurality of EEG sensors;
a processor in communication with the input and configured to;
i) receive the EEG signals from the input;
ii) assemble a set of time-series data using the EEG signals received;
iii) analyze the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state;
iv) identify a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified in (iii), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject'"'"'s brain;
v) compare the burst characteristic profile against a reference set of burst profiles; and
vi) determine, based on the comparison of (v), a likelihood of a brain state of the subject underlying the burst suppression state; and
a display configured to provide a report, generated by the processor, indicating the likelihood of the brain state determined in (vi).
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Accused Products
Abstract
Systems and methods are provided for monitoring a subject, and particularly, for inferring an underlying brain state present in absence of current conditions. In some aspects, a method for monitoring the subject is provided including steps of receiving physiological feedback from at least one sensor configured to acquire physiological information from locations associated with a subject'"'"'s brain, assembling a set of time-series data using the received physiological feedback, and identifying portions of the set of time-series data that indicate a burst suppression state. The method also includes identifying a burst characteristic profile associated with a burst pattern determined from the identified portions, and comparing the burst characteristic against a reference set of burst profiles. The method further includes determining, based on the comparison, a likelihood of a brain state of the subject underlying the burst suppression state, and generating a report indicative of the likelihood of the determined brain state.
92 Citations
16 Claims
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1. A system for monitoring a subject, the system comprising:
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a plurality of electroencephalogram (EEG) sensors configured to acquire EEG signals from multiple locations about a subject'"'"'s brain; an input configured to receive at least the EEG signals from the plurality of EEG sensors; a processor in communication with the input and configured to; i) receive the EEG signals from the input; ii) assemble a set of time-series data using the EEG signals received; iii) analyze the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state; iv) identify a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified in (iii), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject'"'"'s brain; v) compare the burst characteristic profile against a reference set of burst profiles; and vi) determine, based on the comparison of (v), a likelihood of a brain state of the subject underlying the burst suppression state; and a display configured to provide a report, generated by the processor, indicating the likelihood of the brain state determined in (vi). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for monitoring a subject comprising steps of:
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(a) acquiring electroencephalogram (EEG) signals from multiple locations about a subject'"'"'s brain using a plurality of EEG sensors positioned thereabout; and using a processor (b) assembling a set of time-series data using the EEG signals acquired; (c) analyzing the set of time-series data to identify burst or burst suppression epochs corresponding to a burst suppression state; (d) identifying a burst characteristic profile for the subject based on a burst pattern determined from the epochs identified at step (c), wherein the burst pattern represents spatial and temporal occurrences of bursts across cortical regions of the subject'"'"'s brain; (e) comparing the burst characteristic profile against a reference set of burst profiles; (f) determining, based on the comparison of step (e), a likelihood of a brain state of the subject underlying the burst suppression state; and (g) generating a report indicative of the likelihood of the brain state determined in step (f). - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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Specification